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The safety and efficacy of intra-arterial low-dose tirofiban administration during endovascular therapy in patients with large ischemic core volume

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dc.contributor.author조광천-
dc.date.accessioned2024-05-23T03:23:37Z-
dc.date.available2024-05-23T03:23:37Z-
dc.date.issued2024-02-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/199217-
dc.description.abstractThis study aimed to evaluate the safety and efficacy of intra-arterial (IA) administration of low- dose tirofiban during endovascular therapy in patients with large ischemic core volumes on initial brain CT. Patients were divided into two groups based on the use of IA tirofiban. We identified 87 patients (16 and 71 patients in the tirofiban and no-tirofiban groups, respectively) with acute ischemic stroke due to intracranial artery occlusion who underwent endovascular therapy with a low Alberta Stroke Program Early CT scores (2–5). Multivariate logistic regression analysis revealed no association between IA tirofiban administration and serious postprocedural hemorrhagic complications (adjusted odds ratio (aOR), 0.720; 95% confidence interval (CI) 0.099–5.219; p = 0.960), any radiologic hemorrhage (aOR 0.076; 95% CI 0.003–2.323; p = 0.139), or 3-month mortality (aOR, 0.087; 95% CI 0.005–1.501; p = 0.093). However, IA tirofiban was associated with a lower 90-day mRS score (aOR, 0.197; 95% CI 0.015–1.306; p = 0.017) and change of NIHSS compared with baseline (aOR, 0.698; 95% CI 0.531–0.917; p = 0.010). IA tirofiban administration during endovascular therapy in patients with large ischemic core volumes may be effective and safe. © The Author(s) 2024.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHBrain Ischemia* / drug therapy-
dc.subject.MESHEndovascular Procedures* / adverse effects-
dc.subject.MESHFibrinolytic Agents / therapeutic use-
dc.subject.MESHHumans-
dc.subject.MESHIschemic Stroke* / etiology-
dc.subject.MESHStroke* / therapy-
dc.subject.MESHTirofiban-
dc.subject.MESHTreatment Outcome-
dc.titleThe safety and efficacy of intra-arterial low-dose tirofiban administration during endovascular therapy in patients with large ischemic core volume-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학교실)-
dc.contributor.googleauthorKwang-Chun Cho-
dc.contributor.googleauthorNak-Hoon Son-
dc.contributor.googleauthorSo Hyeon Gwon-
dc.contributor.googleauthorJin Wook Choi-
dc.contributor.googleauthorWoo Sang Jung-
dc.identifier.doi10.1038/s41598-024-53715-8-
dc.contributor.localIdA05416-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid38336813-
dc.subject.keywordAcute ischemic stroke-
dc.subject.keywordAlberta Stroke Program Early CT Score-
dc.subject.keywordEndovascular therapy-
dc.subject.keywordTirofiban-
dc.contributor.alternativeNameCho, Kwang Chun-
dc.contributor.affiliatedAuthor조광천-
dc.citation.volume14-
dc.citation.number1-
dc.citation.startPage3353-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.14(1) : 3353, 2024-02-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers

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