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Metabolic dysfunction-associated steatotic liver disease and risk of cardiovascular disease

Authors
 Hyeok-Hee Lee  ;  Han Ah Lee  ;  Eun-Jin Kim  ;  Hwi Young Kim  ;  Hyeon Chang Kim  ;  Sang Hoon Ahn  ;  Hokyou Lee  ;  Seung Up Kim 
Citation
 GUT, Vol.73(3) : 533-540, 2024-03 
Journal Title
GUT
ISSN
 0017-5749 
Issue Date
2024-03
MeSH
Adult ; Brain Ischemia* ; Cardiovascular Diseases* / epidemiology ; Cardiovascular Diseases* / etiology ; Humans ; Metabolic Diseases* / complications ; Metabolic Diseases* / epidemiology ; Non-alcoholic Fatty Liver Disease* / complications ; Non-alcoholic Fatty Liver Disease* / epidemiology ; Stroke*
Keywords
CARDIOVASCULAR COMPLICATIONS ; CARDIOVASCULAR DISEASE ; FATTY LIVER ; LIVER ; NONALCOHOLIC STEATOHEPATITIS
Abstract
ObjectiveWe explored clinical implications of the new definition of metabolic dysfunction-associated steatotic liver disease (MASLD) by assessing its prevalence and associated cardiovascular disease (CVD) risk.DesignFrom nationwide health screening data, we identified 9 775 066 adults aged 20-79 who underwent health examination in 2009. Participants were categorised into four mutually exclusive groups: (1) MASLD; (2) MASLD with increased alcohol intake (MetALD); (3) MASLD with other combined aetiology (the three collectively referred to as MASLD/related steatotic liver disease (SLD)); and (4) no MASLD/related SLD. SLD was determined by fatty liver index >= 30. The primary outcome was CVD event, defined as a composite of myocardial infarction, ischaemic stroke, heart failure or cardiovascular death.ResultsThe prevalence of MASLD, MetALD and MASLD with other combined aetiology was 27.5%, 4.4% and 1.5%, respectively. A total of 8 808 494 participants without prior CVD were followed up for a median of 12.3 years, during which 272 863 CVD events occurred. The cumulative incidence and multivariable-adjusted risk of CVD were higher in participants with MASLD/related SLD than in those without (HR 1.38 (95% CI 1.37 to 1.39)). Multivariable-adjusted HR (95% CI) of CVD events was 1.39 (1.38 to 1.40) for MASLD, 1.28 (1.26 to 1.30) for MetALD and 1.30 (1.26 to 1.34) for MASLD with other combined aetiology compared to the absence of any of these conditions. CVD risk was also higher in participants with metabolic dysfunction-associated fatty liver disease or non-alcoholic fatty liver disease than in those without the respective condition.ConclusionOver one-third of Korean adults have MASLD/related SLD and bear a high CVD risk.
Full Text
https://gut.bmj.com/content/73/3/533.long
DOI
10.1136/gutjnl-2023-331003
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Lee, Hyeok-Hee(이혁희)
Lee, Hokyou(이호규) ORCID logo https://orcid.org/0000-0002-5034-8422
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/199201
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