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The assessment of halitosis with a new screening tool in medication-related osteonecrosis of the jaw

Authors
 Yiseul Choi  ;  Jaeyeon Kim  ;  Yumie Rhee  ;  Jin Hoo Park  ;  Woong Nam  ;  Wonse Park 
Citation
 CLINICAL ORAL INVESTIGATIONS, Vol.28(1) : 102, 2024-01 
Journal Title
CLINICAL ORAL INVESTIGATIONS
ISSN
 1432-6981 
Issue Date
2024-01
MeSH
Bisphosphonate-Associated Osteonecrosis of the Jaw* / diagnosis ; Bone Density Conservation Agents* ; Diphosphonates ; Halitosis* / diagnosis ; Humans ; Hydrogen ; Hydrogen Sulfide* ; Male ; Osteonecrosis* ; Osteoporosis* ; Sulfhydryl Compounds
Keywords
Halitosis ; Hydrogen sulfide ; Medication-related osteonecrosis of the jaw ; Methyl mercaptan ; Osteoporosis ; Volatile sulfur compounds
Abstract
Objectives: This study aimed to identify the levels of halitosis in patients with Medication-related osteonecrosis of the jaw (MRONJ) and osteoporosis and to suggest a new MRONJ screening method using halitosis measurement. Materials and Methods: From October 2019 to April 2023, participants aged 19 years or older without periodontal disease were selected. Seventy-five participants, 25 in each group, were divided into an MRONJ group, an osteoporosis group without MRONJ, and a control group without osteoporosis and not taking osteoporosis drugs or antibiotics. Each participant underwent halitosis assessment twice using an exhaled breath analyzer to measure halitosis twice by blowing a straw for 1 min. Measured concentrations of hydrogen, hydrogen sulfide, and methyl mercaptan were compared between groups. Results: Data from 22 patients in the MRONJ group, 25 in the osteoporosis group, and 25 in the control group were analyzed. The concentrations of hydrogen sulfide and methyl mercaptan were significantly higher in the MRONJ group than in the other groups, but the concentrations of hydrogen did not differ between the groups. When comparing the concentrations of hydrogen sulfide and methyl mercaptan in osteoporosis patients and solid cancer patients in the MRONJ group, there was a significant difference in hydrogen sulfide concentration, but there was no significant difference in methyl mercaptan. Conclusions: Quantifying the level of halitosis can be used to screen for MRONJ in patients taking bisphosphonates, such as patients with osteoporosis, prostate cancer, and breast cancer. Clinical Relevance: MRONJ is accompanied by bad breath, and the concentrations of hydrogen sulfide and methyl mercaptan are associated with MRONJ. © 2024, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Full Text
https://link.springer.com/article/10.1007/s00784-024-05506-8
DOI
10.1007/s00784-024-05506-8
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Advanced General Dentistry (통합치의학과) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Nam, Woong(남웅) ORCID logo https://orcid.org/0000-0003-0146-3624
Park, Wonse(박원서) ORCID logo https://orcid.org/0000-0002-2081-1156
Park, Jin Hoo(박진후) ORCID logo https://orcid.org/0000-0003-2337-9554
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
Choi, Yiseul(최이슬)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/199197
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