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Clinical, qualitative imaging biomarkers, and tumor oxygenation imaging biomarkers for differentiation of midline-located IDH wild-type glioblastomas and H3 K27-altered diffuse midline gliomas in adults

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dc.contributor.author김세훈-
dc.contributor.author박예원-
dc.contributor.author안성수-
dc.contributor.author이나래-
dc.contributor.author이승구-
dc.contributor.author장종희-
dc.contributor.author최서희-
dc.date.accessioned2024-05-23T03:05:48Z-
dc.date.available2024-05-23T03:05:48Z-
dc.date.issued2024-04-
dc.identifier.issn0720-048X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/199158-
dc.description.abstractPurpose: To compare the clinical, qualitative and quantitative imaging phenotypes, including tumor oxygenation characteristics of midline-located IDH-wildtype glioblastomas (GBMs) and H3 K27-altered diffuse midline gliomas (DMGs) in adults. Methods: Preoperative MRI data of 55 adult patients with midline-located IDH-wildtype GBM or H3 K27-altered DMG (32 IDH-wildtype GBM and 23 H3 K27-altered DMG patients) were included. Qualitative imaging assessment was performed. Quantitative imaging assessment including the tumor volume, normalized cerebral blood volume, capillary transit time heterogeneity (CTH), oxygen extraction fraction (OEF), relative cerebral metabolic rate of oxygen values, and mean ADC value were performed from the tumor mask via automatic segmentation. Univariable and multivariable logistic analyses were performed. Results: On multivariable analysis, age (odds ratio [OR] = 0.92, P = 0.015), thalamus or medulla location (OR = 10.48, P = 0.013), presence of necrosis (OR = 0.15, P = 0.038), and OEF (OR = 0.01, P = 0.042) were independent predictors to differentiate H3 K27-altered DMG from midline-located IDH-wildtype GBM. The area under the curve, accuracy, sensitivity, and specificity of the multivariable model were 0.88 (95 % confidence interval: 0.77–0.95), 81.8 %, 82.6 %, and 81.3 %, respectively. Conclusions: Along with younger age, tumor location, less frequent necrosis, and lower OEF may be useful imaging biomarkers to differentiate H3 K27-altered DMG from midline-located IDH-wildtype GBM. Tumor oxygenation imaging biomarkers may reflect the less hypoxic nature of H3 K27-altered DMG than IDH-wildtype GBM and may contribute to differentiation.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier Science Ireland Ltd-
dc.relation.isPartOfEUROPEAN JOURNAL OF RADIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHBiomarkers, Tumor / genetics-
dc.subject.MESHBrain Neoplasms* / pathology-
dc.subject.MESHGlioblastoma* / pathology-
dc.subject.MESHGlioma* / pathology-
dc.subject.MESHHumans-
dc.subject.MESHMutation-
dc.subject.MESHNecrosis-
dc.subject.MESHOxygen-
dc.titleClinical, qualitative imaging biomarkers, and tumor oxygenation imaging biomarkers for differentiation of midline-located IDH wild-type glioblastomas and H3 K27-altered diffuse midline gliomas in adults-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학교실)-
dc.contributor.googleauthorYongsik Sim-
dc.contributor.googleauthorSeo Hee Choi-
dc.contributor.googleauthorNarae Lee-
dc.contributor.googleauthorYae Won Park-
dc.contributor.googleauthorSung Soo Ahn-
dc.contributor.googleauthorJong Hee Chang-
dc.contributor.googleauthorSe Hoon Kim-
dc.contributor.googleauthorSeung-Koo Lee-
dc.identifier.doi10.1016/j.ejrad.2024.111384-
dc.contributor.localIdA00610-
dc.contributor.localIdA05330-
dc.contributor.localIdA02234-
dc.contributor.localIdA02703-
dc.contributor.localIdA02912-
dc.contributor.localIdA03470-
dc.contributor.localIdA04867-
dc.relation.journalcodeJ00845-
dc.identifier.eissn1872-7727-
dc.identifier.pmid38422610-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0720048X24001001-
dc.subject.keywordAdult-
dc.subject.keywordDiffuse midline glioma-
dc.subject.keywordGlioblastoma-
dc.subject.keywordPerfusion magnetic resonance imaging-
dc.contributor.alternativeNameKim, Se Hoon-
dc.contributor.affiliatedAuthor김세훈-
dc.contributor.affiliatedAuthor박예원-
dc.contributor.affiliatedAuthor안성수-
dc.contributor.affiliatedAuthor이나래-
dc.contributor.affiliatedAuthor이승구-
dc.contributor.affiliatedAuthor장종희-
dc.contributor.affiliatedAuthor최서희-
dc.citation.volume173-
dc.citation.startPage111384-
dc.identifier.bibliographicCitationEUROPEAN JOURNAL OF RADIOLOGY, Vol.173 : 111384, 2024-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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