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Dopamine transporter positron emission tomography in patients with Alzheimer's disease with Lewy body disease features

Authors
 Sungwoo Kang  ;  Seun Jeon  ;  Young-Gun Lee  ;  Byoung Seok Ye 
Citation
 NEUROBIOLOGY OF AGING, Vol.134 : 57-65, 2024-02 
Journal Title
NEUROBIOLOGY OF AGING
ISSN
 0197-4580 
Issue Date
2024-02
MeSH
Alzheimer Disease* / diagnostic imaging ; Dopamine Plasma Membrane Transport Proteins ; Humans ; Lewy Body Disease* / diagnostic imaging ; Positron-Emission Tomography ; Tomography, Emission-Computed, Single-Photon / methods
Keywords
Alzheimer’s disease ; Dopamine transporter ; Lewy body disease ; Parkinsonism
Abstract
In 36 normal controls (NC), 37 patients with Alzheimer's disease (AD) without parkinsonism (ADP-), 31 AD with parkinsonism (ADP+), and 40 AD with dementia with Lewy bodies (ADDLB), dual-phase dopamine transporter (DAT) positron emission tomography (PET) were performed to evaluate the diagnostic performance of DAT and early-to-delayed uptake ratios (E/Ds) in the anterior caudate (AC), posterior caudate (PC), anterior putamen (AP), posterior putamen (PP), and substantia nigra (SN) to differentiate ADP+/ADDLB from NC, and their effects on parkinsonism and cognition. DAT-SN and E/D-PP showed higher accuracies to differentiate ADP+/ADDLB from NC than DAT-PP. Among AD patients, lower DAT in the putamen and PC and higher E/Ds in the striatum were associated with severe parkinsonism, while higher E/Ds in the putamen, PC, and SN were associated with executive dysfunction. Our results suggest that decreased DAT-SN and increased E/D-PP could be biomarkers differentiating ADP+/ADDLB from pure AD and controls. Meanwhile, increased E/Ds in the putamen could reflect the severity of DLB presenting with parkinsonism and executive dysfunction among AD patients. © 2023 Elsevier Inc.
Full Text
https://www.sciencedirect.com/science/article/pii/S0197458023002452
DOI
10.1016/j.neurobiolaging.2023.10.008
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Ye, Byoung Seok(예병석) ORCID logo https://orcid.org/0000-0003-0187-8440
Jeon, Seun(전세운) ORCID logo https://orcid.org/0000-0003-2817-3352
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/199114
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