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Serial mediating effects of childhood trauma and conduct behaviors on the impact of family history among patients with alcohol use disorder

Authors
 Min Jeong Han  ;  Shin Tae Kim  ;  Chun Il Park  ;  Syung Shick Hwang  ;  Hae Won Kim  ;  Jee In Kang  ;  Se Joo Kim 
Citation
 SCIENTIFIC REPORTS, Vol.14(1) : 7196, 2024-03 
Journal Title
SCIENTIFIC REPORTS
Issue Date
2024-03
MeSH
Adverse Childhood Experiences* ; Alcohol Drinking / psychology ; Alcohol-Related Disorders* ; Alcoholism* / psychology ; Conduct Disorder* ; Humans ; Male
Abstract
Family history (FH) of alcoholism increases the risk of alcohol use disorder (AUD); however, the contribution of childhood trauma (CT) in this respect remains unclear. This study investigated the relationship between FH and AUD-related clinical characteristics (social onset, antisocial tendency, and severity of problematic alcohol consumption) through the mediating effects of childhood trauma (CT) and conduct behaviors (CB) in a Korean male population with AUD. A total of 304 patients hospitalized for AUD at 16 psychiatric hospitals completed standardized questionnaires, including self-rated scales. Mediation analyses were performed using the SPSS macro PROCESS. Individuals with positive FH (133, 44%) had greater CT and CB and more severe AUD-related clinical characteristics than those without FH (171, 56%). In the present serial mediation model, FH had significant direct and indirect effects on AUD-related clinical characteristics through CT and CB. Indirect effects were 21.3% for social onset, 46.3%, antisocial tendency, and 37.9% for problematic drinking. FH directly contributed to AUD-related clinical characteristics, and CT and CB played mediating roles. This highlights the importance of careful intervention and surveillance of adverse childhood experiences and conduct disorder to prevent and mitigate alcohol-related problems in individuals with FH of AUD.
Files in This Item:
T202402188.pdf Download
DOI
10.1038/s41598-024-57861-x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Education (의학교육학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Jee In(강지인) ORCID logo https://orcid.org/0000-0002-2818-7183
Kim, Se Joo(김세주) ORCID logo https://orcid.org/0000-0002-5438-8210
Kim, Hae Won(김혜원) ORCID logo https://orcid.org/0000-0002-9321-8361
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/198879
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