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Effects of concurrent cartilage procedures on cartilage regeneration in high tibial osteotomy: a systematic review

 Joo Hyung Han  ;  Min Jung  ;  Kwangho Chung  ;  Se-Han Jung  ;  Chong-Hyuk Choi  ;  Sung-Hwan Kim 
 Journal of Korean Knee Society (대한슬관절학회지), Vol.36(1) : 13, 2024-03 
Journal Title
Journal of Korean Knee Society(대한슬관절학회지)
Issue Date
Bone marrow aspirate concentrate ; Cartilage regeneration ; High tibial osteotomy ; Human umbilical cord blood-derived mesenchymal stem cell ; Microfracture ; Second-look arthroscopy
PURPOSE: This systematic review aimed to evaluate the effects of concurrent cartilage procedures on cartilage regeneration when performed alongside high tibial osteotomy (HTO). MATERIALS AND METHODS: The systematic review followed the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). A comprehensive search was conducted on databases including PubMed, Embase, Cochrane Library, and Google Scholar, covering articles published until August 31, 2023. RESULTS: Sixteen studies (1277 patients) revealed that HTO, with or without concurrent cartilage procedures, leads to cartilage regeneration based on the International Cartilage Repair Society (ICRS) grade during second-look arthroscopy. No concurrent procedure showed improvement in ICRS grade (mean difference: - 0.80 to - 0.49). Microfracture (mean difference: - 0.75 to - 0.22), bone marrow aspirate concentrate (BMAC) (mean difference: - 1.37 to - 0.67), and human umbilical cord blood-derived mesenchymal stem cell (hUCB-MSC) (mean difference: - 2.46 to - 1.81) procedures also demonstrated positive outcomes. Clinical outcome assessments for each cartilage procedure were also improved during postoperative follow-up, and no specific complications were reported. CONCLUSIONS: HTO with or without concurrent cartilage procedures promotes cartilage regeneration observed during second-look arthroscopy, with improved clinical outcomes. Future randomized controlled trials on the same topic, along with subsequent meta-analyses, are necessary for conclusive findings.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sung Hwan(김성환) ORCID logo https://orcid.org/0000-0001-5743-6241
Chung, Kwangho(정광호) ORCID logo https://orcid.org/0000-0003-3097-3332
Jung, Min(정민) ORCID logo https://orcid.org/0000-0002-7527-4802
Jung, Se-Han(정세한) ORCID logo https://orcid.org/0000-0001-8422-093X
Choi, Chong Hyuk(최종혁) ORCID logo https://orcid.org/0000-0002-9080-4904
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