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Quantitative Analysis of Hair Luster in a Novel Ultraviolet-Irradiated Mouse Model

Authors
 Kyung Bae Chung  ;  Young In Lee  ;  Yoo Jin Kim  ;  Hyeon Ah Do  ;  Jangmi Suk  ;  Inhee Jung  ;  Do-Young Kim  ;  Ju Hee Lee 
Citation
 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.25(3) : 1885, 2024-02 
Journal Title
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN
 1661-6596 
Issue Date
2024-02
MeSH
Alopecia ; Animals ; Disease Models, Animal ; Hair* / radiation effects ; Humans ; Mice ; Mice, Inbred C57BL ; Skin ; Ultraviolet Rays*
Keywords
hair gloss ; hair luster ; hair shaft ; minoxidil ; mouse model ; ultraviolet radiation
Abstract
Hair luster is a key attribute of healthy hair and a crucial aspect of cosmetic appeal, reflecting the overall health and vitality of hair. Despite its significance, the advancement of therapeutic strategies for hair luster enhancement have been limited due to the absence of an effective experimental model. This study aimed to establish a novel animal model to assess hair gloss, employing ultraviolet (UV) irradiation on C57BL/6 mice. Specifically, UVB irradiation was meticulously applied to the shaved skin of these mice, simulating conditions that typically lead to hair luster loss in humans. The regrowth and characteristics of the hair were evaluated using a dual approach: an Investigator’s Global Assessment (IGA) scale for subjective assessment and an image-based pixel-count method for objective quantification. These methods provided a comprehensive understanding of the changes in hair quality post-irradiation. To explore the potential reversibility of hair luster changes, oral minoxidil was administered, a treatment known for its effects on hair growth and texture. Further, to gain insights into the underlying biological mechanisms, bulk RNA transcriptomic analysis of skin tissue was conducted. This analysis revealed significant alterations in the expression of keratin-associated protein (KRTAP) genes, suggesting modifications in hair keratin crosslinking due to UV exposure. These changes are crucial in understanding the molecular dynamics affecting hair luster. The development of this new mouse model is a significant advancement in hair care research. It not only facilitates the evaluation of hair luster in a controlled setting but also opens avenues for the research and development of innovative therapeutic strategies. This model holds promise for the formulation of more effective hair care products and treatments, potentially revolutionizing the approach towards managing and enhancing hair luster. © 2024 by the authors.
Files in This Item:
T202401843.pdf Download
DOI
10.3390/ijms25031885
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영) ORCID logo https://orcid.org/0000-0002-0194-9854
Lee, Young In(이영인) ORCID logo https://orcid.org/0000-0001-6831-7379
Lee, Ju Hee(이주희) ORCID logo https://orcid.org/0000-0002-1739-5956
Chung, Kyung Bae(정경배) ORCID logo https://orcid.org/0000-0002-2121-3553
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/198835
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