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Quantitative Analysis of Hair Luster in a Novel Ultraviolet-Irradiated Mouse Model

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dc.contributor.author김도영-
dc.contributor.author이영인-
dc.contributor.author이주희-
dc.contributor.author정경배-
dc.date.accessioned2024-04-11T06:36:52Z-
dc.date.available2024-04-11T06:36:52Z-
dc.date.issued2024-02-
dc.identifier.issn1661-6596-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/198835-
dc.description.abstractHair luster is a key attribute of healthy hair and a crucial aspect of cosmetic appeal, reflecting the overall health and vitality of hair. Despite its significance, the advancement of therapeutic strategies for hair luster enhancement have been limited due to the absence of an effective experimental model. This study aimed to establish a novel animal model to assess hair gloss, employing ultraviolet (UV) irradiation on C57BL/6 mice. Specifically, UVB irradiation was meticulously applied to the shaved skin of these mice, simulating conditions that typically lead to hair luster loss in humans. The regrowth and characteristics of the hair were evaluated using a dual approach: an Investigator’s Global Assessment (IGA) scale for subjective assessment and an image-based pixel-count method for objective quantification. These methods provided a comprehensive understanding of the changes in hair quality post-irradiation. To explore the potential reversibility of hair luster changes, oral minoxidil was administered, a treatment known for its effects on hair growth and texture. Further, to gain insights into the underlying biological mechanisms, bulk RNA transcriptomic analysis of skin tissue was conducted. This analysis revealed significant alterations in the expression of keratin-associated protein (KRTAP) genes, suggesting modifications in hair keratin crosslinking due to UV exposure. These changes are crucial in understanding the molecular dynamics affecting hair luster. The development of this new mouse model is a significant advancement in hair care research. It not only facilitates the evaluation of hair luster in a controlled setting but also opens avenues for the research and development of innovative therapeutic strategies. This model holds promise for the formulation of more effective hair care products and treatments, potentially revolutionizing the approach towards managing and enhancing hair luster. © 2024 by the authors.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAlopecia-
dc.subject.MESHAnimals-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHHair* / radiation effects-
dc.subject.MESHHumans-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHSkin-
dc.subject.MESHUltraviolet Rays*-
dc.titleQuantitative Analysis of Hair Luster in a Novel Ultraviolet-Irradiated Mouse Model-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Dermatology (피부과학교실)-
dc.contributor.googleauthorKyung Bae Chung-
dc.contributor.googleauthorYoung In Lee-
dc.contributor.googleauthorYoo Jin Kim-
dc.contributor.googleauthorHyeon Ah Do-
dc.contributor.googleauthorJangmi Suk-
dc.contributor.googleauthorInhee Jung-
dc.contributor.googleauthorDo-Young Kim-
dc.contributor.googleauthorJu Hee Lee-
dc.identifier.doi10.3390/ijms25031885-
dc.contributor.localIdA00384-
dc.contributor.localIdA05880-
dc.contributor.localIdA03171-
dc.relation.journalcodeJ01133-
dc.identifier.eissn1422-0067-
dc.identifier.pmid38339167-
dc.subject.keywordhair gloss-
dc.subject.keywordhair luster-
dc.subject.keywordhair shaft-
dc.subject.keywordminoxidil-
dc.subject.keywordmouse model-
dc.subject.keywordultraviolet radiation-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.affiliatedAuthor김도영-
dc.contributor.affiliatedAuthor이영인-
dc.contributor.affiliatedAuthor이주희-
dc.citation.volume25-
dc.citation.number3-
dc.citation.startPage1885-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.25(3) : 1885, 2024-02-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers

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