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CSMP: A Self-Assembled Plant Polysaccharide-Based Hydrofilm for Enhanced Wound Healing

Authors
 Zhen Qiao  ;  KeLun Zhang  ;  Huifang Liu  ;  Yeonjeong Roh  ;  Myoung Gyu Kim  ;  Hyo Joo Lee  ;  Bonhan Koo  ;  Eun Yeong Lee  ;  Minju Lee  ;  Chang Ook Park  ;  Yong Shin 
Citation
 ADVANCED HEALTHCARE MATERIALS, Vol.13(6) : 1-15, 2024-03 
Journal Title
ADVANCED HEALTHCARE MATERIALS
ISSN
 2192-2640 
Issue Date
2024-03
MeSH
Animals ; Anti-Bacterial Agents* ; Bandages ; Cell Movement ; Glycerol / pharmacology ; Hydrogels / pharmacology ; Wound Healing*
Keywords
antibacterial effects ; chia mucilage ; hydrofilms ; tissue adhesiveness ; wound healing
Abstract
Wound management remains a critical healthcare issue due to the rising incidence of chronic diseases leading to persistent wounds. Traditional dressings have their limitations, such as potential for further damage during changing and suboptimal healing conditions. Recently, hydrogel-based dressings have gained attention due to their biocompatibility, biodegradability, and ability to fill wounds. Particularly, polysaccharide-based hydrogels have shown potential in various medical applications. This study focuses on the development of a novel hydrofilm wound dressing produced from a blend of chia seed mucilage (CSM) and polyvinyl alcohol (PVA), termed CSMP. While the individual properties of CSM and PVA are well-documented, their combined potential in wound management is largely unexplored. CSMP, coupled with sorbitol and glycerin, and cross-linked using ultraviolet light, results in a flexible, adhesive, and biocompatible hydrofilm demonstrating superior water absorption, moisturizing, and antibacterial properties. This hydrofilm promotes epithelial cell migration, enhanced collagen production, and outperforms existing commercial dressings in animal tests. The innovative CSMP hydrofilm offers a promising, cost-effective approach for improved wound care, bridging existing gaps in dressing performance and preparation simplicity. Future research can unlock further applications of such polysaccharide-based hydrofilm dressings.
Full Text
https://onlinelibrary.wiley.com/doi/10.1002/adhm.202303244
DOI
10.1002/adhm.202303244
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Park, Chang Ook(박창욱) ORCID logo https://orcid.org/0000-0003-3856-1201
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/198733
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