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Skin microbe-dependent TSLP-ILC2 priming axis in early life is co-opted in allergic inflammation

Authors
 Jimin Cha  ;  Tae-Gyun Kim  ;  Euihyun Bhae  ;  Ho-Jin Gwak  ;  Yeajin Ju  ;  Young Ho Choe  ;  In-Hwan Jang  ;  Youngae Jung  ;  Sungmin Moon  ;  Taehyun Kim  ;  Wuseong Lee  ;  Jung Sun Park  ;  Youn Wook Chung  ;  Siyoung Yang  ;  Yong-Kook Kang  ;  Young-Min Hyun  ;  Geum-Sook Hwang  ;  Won-Jae Lee  ;  Mina Rho  ;  Ji-Hwan Ryu 
Citation
 CELL HOST & MICROBE, Vol.32(2) : 244-260, 2024-02 
Journal Title
CELL HOST & MICROBE
ISSN
 1931-3128 
Issue Date
2024-02
MeSH
Adult ; Cytokines / metabolism ; Dermatitis, Atopic* ; Humans ; Immunity, Innate ; Infant, Newborn ; Inflammation ; Lymphocytes ; Skin / metabolism ; Thymic Stromal Lymphopoietin*
Keywords
Staphylococcus ; allergic skin inflammation ; atopic dermatitis ; early postnatal life ; group 2 innate lymphoid cells ; priming ; skin microbiota ; tryptophan metabolites
Abstract
Although early life colonization of commensal microbes contributes to long-lasting immune imprinting in host tissues, little is known regarding the pathophysiological consequences of postnatal microbial tuning of cutaneous immunity. Here, we show that postnatal exposure to specific skin commensal Staphylococcus lentus (S. lentus) promotes the extent of atopic dermatitis (AD)-like inflammation in adults through priming of group 2 innate lymphoid cells (ILC2s). Early postnatal skin is dynamically populated by discrete subset of primed ILC2s driven by microbiota-dependent induction of thymic stromal lymphopoietin (TSLP) in keratinocytes. Specifically, the indole-3-aldehyde-producing tryptophan metabolic pathway, shared across Staphylococcus species, is involved in TSLP-mediated ILC2 priming. Furthermore, we demonstrate a critical contribution of the early postnatal S. lentus-TSLP-ILC2 priming axis in facilitating AD-like inflammation that is not replicated by later microbial exposure. Thus, our findings highlight the fundamental role of time-dependent neonatal microbial-skin crosstalk in shaping the threshold of innate type 2 immunity co-opted in adulthood.
Full Text
https://www.sciencedirect.com/science/article/pii/S1931312823005012
DOI
10.1016/j.chom.2023.12.006
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Tae-Gyun(김태균) ORCID logo https://orcid.org/0000-0002-2116-4579
Ryu, Ji Hwan(유지환)
Hyun, Young-Min(현영민) ORCID logo https://orcid.org/0000-0002-0567-2039
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/198680
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