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Regulation of sexually dimorphic placental adaptation in LPS exposure-induced intrauterine growth restriction

Authors
 Da Som Jeong  ;  Ji-Yeon Lee  ;  Myoung Hee Kim  ;  Ji Hoon Oh 
Citation
 MOLECULAR MEDICINE, Vol.29(1) : 114, 2023-09 
Journal Title
MOLECULAR MEDICINE
ISSN
 1076-1551 
Issue Date
2023-09
MeSH
Animals ; Female ; Fetal Growth Retardation* / chemically induced ; Humans ; Lipopolysaccharides* ; Male ; Mice ; Mice, Inbred ICR ; Placenta ; Pregnancy ; RNA
Keywords
Intrauterine growth restriction ; Placenta transcriptome ; Placental adaptation ; Prenatal maternal stress ; Sexual dimorphism
Abstract
Background: Sexual dimorphism in placental physiology affects the functionality of placental adaptation during adverse pregnancy. Defects of placental function compromise fetal programming, affecting the offspring’s adult life. However, studies focusing on the relationship between sex-specific placental adaptation and consequent fetal maldevelopment under sub-optimal uterus milieu are still elusive. Methods: Here, we investigated the effects of maternal lipopolysaccharide (LPS) exposure between placental sex. Pregnant ICR mice received intraperitoneal injection of phosphate-buffered saline or 100, 200, and 400 µg/kg LPS on the gestational day (GD) 15.5. To determine whether prenatal maternal LPS exposure resulted in complicated pregnancy outcomes, survival rate of embryos was calculated and the growth of embryos and placentas was examined. To elucidate global transcriptomic changes occurring in the placenta, total RNA-sequencing (RNA-seq) was performed in female and male placentas. Results: LPS administration induced placental inflammation in both sexes at GD 17.5. Prenatal infection resulted in growth retardation in both sexes of embryos, and especially more prevalently in male. Impaired placental development was observed in a sex-specific manner. LPS 400 µg/kg reduced the percentage area of the labyrinth in females and junctional zone in males, respectively. RNA-sequencing revealed widespread sexually dimorphic transcriptional changes in placenta. In particular, representative changes were involved in biological processes such as trophoblast differentiation, nutrient/ion transporter, pregnancy, and immune system. Conclusions: Our results present the sexually dimorphic responses of placental physiology in intrauterine growth restriction model and provide tentative relationship further to be elucidated between sex-biased placental functional change and long-term effects on the offspring’s later life. © 2023, The Feinstein Institute for Medical Research.
Files in This Item:
T999202643.pdf Download
DOI
10.1186/s10020-023-00688-5
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myoung Hee(김명희) ORCID logo https://orcid.org/0000-0001-5652-1452
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/198443
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