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Clinical and Radiological Features of Korean Patients With Anti-HMGCR Myopathy

DC Field Value Language
dc.contributor.author김성준-
dc.contributor.author김승우-
dc.contributor.author신하영-
dc.contributor.author차윤진-
dc.contributor.author최영철-
dc.contributor.author박형준-
dc.date.accessioned2024-03-22T05:48:04Z-
dc.date.available2024-03-22T05:48:04Z-
dc.date.issued2023-09-
dc.identifier.issn1738-6586-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/198214-
dc.description.abstractBackground and Purpose To understand the characteristics of Korean patients with anti-3-hydroxy-3-methylglutaryl-coenxyme A reductase (HMGCR) myopathy, we measured anti-HMGCR antibodies and analyzed the clinical, radiological, and pathological features of patients with anti-HMGCR myopathy. Methods We measured titers of anti-HMGCR antibodies in the sera of 99 patients with inflammatory myopathy, 36 patients with genetic myopathy, and 63 healthy subjects using an enzyme-linked immunosorbent assay. We tested 16 myositis-specific autoantibodies (MSAs) in all patients with anti-HMGCR myopathy. Results Positivity for the anti-HMGCR antibody was observed in 17 (4 males and 13 females) of 99 patients with inflammatory myopathy. The median age at symptom onset was 60 years. Ten (59%) of the patients with anti-HMGCR positivity had taken statins. The titer of anti-HMGCR antibodies was significantly higher in the statin-naïve group (median=230 U/mL, interquartile range=170–443 U/mL) than in the statin-exposed group (median=178 U/mL, interquartile range=105–210 U/mL, p=0.045). The most common symptom was proximal muscle weakness in 15 patients (88%), followed by myalgia in 9 (53%), neck weakness in 4 (24%), dysphagia in 3 (18%), and skin lesions in 2 (12%). The median titer of anti-HMGCR antibody was 202 U/mL. We found eight different MSAs in nine (53%) patients. The median disease duration from symptom onset to diagnosis was significantly shorter in the MSA-positive group than in the MSA-negative group (p=0.027). Conclusions Our study was the first to measure anti-HMGCR antibodies in inflammatory myopathy. It has provided new findings, including the suggestion of the coexistence of other MSAs in Korean patients. © 2023 Korean Neurological Association.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherKorean Neurological Association-
dc.relation.isPartOfJOURNAL OF CLINICAL NEUROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleClinical and Radiological Features of Korean Patients With Anti-HMGCR Myopathy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.googleauthorEun Kyoung Oh-
dc.contributor.googleauthorSeung-Ah Lee-
dc.contributor.googleauthorHyun Joon Lee-
dc.contributor.googleauthorYoon Jin Cha-
dc.contributor.googleauthorSungjun Kim-
dc.contributor.googleauthorHyung-Soo Lee-
dc.contributor.googleauthorBum Chun Suh-
dc.contributor.googleauthorHa Young Shin-
dc.contributor.googleauthorSeung Woo Kim-
dc.contributor.googleauthorByeol-A Yoon-
dc.contributor.googleauthorSeong-Il Oh-
dc.contributor.googleauthorYoo Hwan Kim-
dc.contributor.googleauthorJoong-Yang Cho-
dc.contributor.googleauthorJeong Hee Cho-
dc.contributor.googleauthorKi-Han Kwon-
dc.contributor.googleauthorYoung-Chul Choi-
dc.contributor.googleauthorHyung Jun Park-
dc.identifier.doi10.3988/jcn.2022.0374-
dc.contributor.localIdA00585-
dc.contributor.localIdA04901-
dc.contributor.localIdA02170-
dc.contributor.localIdA04001-
dc.contributor.localIdA04116-
dc.relation.journalcodeJ01327-
dc.identifier.eissn2005-5013-
dc.identifier.pmid36929062-
dc.subject.keywordHMGCR-
dc.subject.keywordautoantibodies-
dc.subject.keywordenzyme-linked immunosorbent assay-
dc.subject.keywordmyositis-
dc.subject.keywordnecrotizing myopathy-
dc.contributor.alternativeNameKim, Sungjun-
dc.contributor.affiliatedAuthor김성준-
dc.contributor.affiliatedAuthor김승우-
dc.contributor.affiliatedAuthor신하영-
dc.contributor.affiliatedAuthor차윤진-
dc.contributor.affiliatedAuthor최영철-
dc.citation.volume19-
dc.citation.number5-
dc.citation.startPage460-
dc.citation.endPage468-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL NEUROLOGY, Vol.19(5) : 460-468, 2023-09-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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