0 308

Cited 1 times in

Nanoscale Magneto-mechanical-genetics of Deep Brain Neurons Reversing Motor Deficits in Parkinsonian Mice

Authors
 Wookjin Shin  ;  Yeongdo Lee  ;  Jueun Lim  ;  Youbin Lee  ;  Jungsu David Lah  ;  Somin Lee  ;  Jung-Uk  ;  Lee Ri Yu  ;  Phil Hyu Lee  ;  Jae-Hyun Lee  ;  Minsuk Kwak  ;  Jinwoo Cheon 
Citation
 NANO LETTERS, Vol.24(1) : 270-278, 2023-12 
Journal Title
NANO LETTERS
ISSN
 1530-6984 
Issue Date
2023-12
MeSH
Animals ; Deep Brain Stimulation* ; Ion Channels ; Mice ; Neurons / physiology ; Parkinson Disease* / genetics ; Parkinson Disease* / therapy ; Parkinsonian Disorders* / therapy ; Subthalamic Nucleus* / physiology
Keywords
Parkinson’s disease ; Piezo1 ion channel ; deep brain stimulation ; magnetic nanoparticles ; magnetogenetics ; subthalamic nucleus (STN)
Abstract
Here, we introduce the magneto-mechanical-genetic (MMG)-driven wireless deep brain stimulation (DBS) using magnetic nanostructures for therapeutic benefits in the mouse model of Parkinson’s disease (PD). Electrical DBS of the subthalamic nucleus (STN) is an effective therapy for mitigating Parkinson’s motor symptoms. However, its broader application is hampered by the requirement for implanted electrodes and the lack of anatomical and cellular specificity. Using the nanoscale magnetic force actuators (m-Torquer), which deliver torque force under rotating magnetic fields to activate pre-encoded Piezo1 ion channels on target neurons, our system enables wireless and STN-specific DBS without implants, addressing key unmet challenges in the DBS field. In both late- and early-stage PD mice, MMG-DBS significantly improved locomotor activity and motor balance by 2-fold compared to untreated PD mice. Moreover, MMG-DBS enabled sustained therapeutic effects. This approach provides a non-invasive and implant-free DBS with cellular targeting capability for the effective treatment of Parkinsonian symptoms. © 2023 American Chemical Society.
Full Text
https://pubs.acs.org/doi/10.1021/acs.nanolett.3c03899
DOI
10.1021/acs.nanolett.3c03899
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/198114
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links