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19F-FDG PET/CT Parameters Enhance MRI Radiomics for Predicting Human Papilloma Virus Status in Oropharyngeal Squamous Cell Carcinoma
DC Field | Value | Language |
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dc.contributor.author | 강원준 | - |
dc.contributor.author | 김진아 | - |
dc.contributor.author | 손범석 | - |
dc.contributor.author | 이승구 | - |
dc.contributor.author | 조호진 | - |
dc.date.accessioned | 2024-02-15T06:36:05Z | - |
dc.date.available | 2024-02-15T06:36:05Z | - |
dc.date.issued | 2023-12 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/197964 | - |
dc.description.abstract | Purpose: Predicting human papillomavirus (HPV) status is critical in oropharyngeal squamous cell carcinoma (OPSCC) ra diomics. In this study, we developed a model for HPV status prediction using magnetic resonance imaging (MRI) radiomics and 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) parameters in patients with OPSCC. Materials and Methods: Patients with OPSCC who underwent 18F-FDG PET/CT and contrast-enhanced MRI before treatment between January 2012 and February 2020 were enrolled. Training and test sets (3:2) were randomly selected. 18F-FDG PET/CT parameters and MRI radiomics feature were extracted. We developed three light-gradient boosting machine prediction models using the training set: Model 1, MRI radiomics features; Model 2,18F-FDG PET/CT parameters; and Model 3, combination of MRI radiomics features and 18F-FDG PET/CT parameters. Area under the receiver operating characteristic curve (AUROC) values were used to analyze the performance of the models in predicting HPV status in the test set. Results: A total of 126 patients (118 male and 8 female; mean age: 60 years) were included. Of these, 103 patients (81.7%) were HPV-positive, and 23 patients (18.3%) were HPV-negative. AUROC values in the test set were 0.762 [95% confidence interval (CI), 0.564–0.959], 0.638 (95% CI, 0.404–0.871), and 0.823 (95% CI, 0.668–0.978) for Models 1, 2, and 3, respectively. The net reclassifica tion improvement of Model 3, compared with that of Model 1, in the test set was 0.119. Conclusion: When combined with an MRI radiomics model, 18F-FDG PET/CT exhibits incremental value in predicting HPV sta tus in patients with OPSCC. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Carcinoma, Squamous Cell* / diagnostic imaging | - |
dc.subject.MESH | Carcinoma, Squamous Cell* / pathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fluorodeoxyglucose F19 | - |
dc.subject.MESH | Head and Neck Neoplasms* | - |
dc.subject.MESH | Human Papillomavirus Viruses | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Papillomavirus Infections* / diagnostic imaging | - |
dc.subject.MESH | Positron Emission Tomography Computed Tomography | - |
dc.subject.MESH | Positron-Emission Tomography | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Squamous Cell Carcinoma of Head and Neck | - |
dc.title | 19F-FDG PET/CT Parameters Enhance MRI Radiomics for Predicting Human Papilloma Virus Status in Oropharyngeal Squamous Cell Carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Nuclear Medicine (핵의학교실) | - |
dc.contributor.googleauthor | Kwan Hyeong Jo | - |
dc.contributor.googleauthor | Jinna Kim | - |
dc.contributor.googleauthor | Hojin Cho | - |
dc.contributor.googleauthor | Won Jun Kang | - |
dc.contributor.googleauthor | Seung-Koo Lee | - |
dc.contributor.googleauthor | Beomseok Sohn | - |
dc.identifier.doi | 10.3349/ymj.2023.0187 | - |
dc.contributor.localId | A00062 | - |
dc.contributor.localId | A01022 | - |
dc.contributor.localId | A04960 | - |
dc.contributor.localId | A02912 | - |
dc.contributor.localId | A03941 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 37992746 | - |
dc.subject.keyword | Positron emission tomography computed tomography | - |
dc.subject.keyword | human papillomavirus | - |
dc.subject.keyword | magnetic resonance imaging | - |
dc.subject.keyword | oropharyngeal cancer | - |
dc.contributor.alternativeName | Kang, Won Jun | - |
dc.contributor.affiliatedAuthor | 강원준 | - |
dc.contributor.affiliatedAuthor | 김진아 | - |
dc.contributor.affiliatedAuthor | 손범석 | - |
dc.contributor.affiliatedAuthor | 이승구 | - |
dc.contributor.affiliatedAuthor | 조호진 | - |
dc.citation.volume | 64 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 738 | - |
dc.citation.endPage | 744 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.64(12) : 738-744, 2023-12 | - |
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