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Two Cases of Frontal Variation of Idiopathic Calvarial Thinning-Therapeutic Effect of Denosumab and Romosozumab

Authors
 Seungjin Baek  ;  Namki Hong  ;  Yumie Rhee 
Citation
 JCEM Case Reports, Vol.1(6) : luad122, 2023-11 
Journal Title
JCEM Case Reports
Issue Date
2023-11
Keywords
bifrontal osteodystrophy ; bilateral thinning of the frontal bones ; denosumab ; idiopathic calvarial thinning ; osteoporosis ; romosozumab
Abstract
Idiopathic calvarial thinning is a rare condition that causes progressive, painless thinning of the skull bones without systemic disease. We present 2 cases of idiopathic calvarial thinning involving the bifrontal region. Both patients exhibited forehead depression and had normal biochemical tests except for mild vitamin D deficiency. The first patient received treatment with denosumab for 3 years, showing no further progression of the skull thinning. The second patient was treated with denosumab for 3 years, followed by romosozumab for 1 year, resulting in no further progression and even slight recovery of the skull thickness. These cases demonstrate that idiopathic calvarial thinning can involve the bifrontal region and highlight the favorable treatment and prognosis with denosumab or romosozumab.
Files in This Item:
T202400303.pdf Download
DOI
10.1210/jcemcr/luad122
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
Hong, Nam Ki(홍남기) ORCID logo https://orcid.org/0000-0002-8246-1956
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/197871
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