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Effectiveness and Usefulness of Bone Turnover Marker in Osteoporosis Patients: A Multicenter Study in Korea

 Jun-Il Yoo  ;  So Young Park  ;  Deog-Yoon Kim  ;  Jeonghoon Ha  ;  Yumie Rhee  ;  Namki Hong  ;  Jung-Taek Kim  ;  Hyon-Seung Yi  ;  Bu Kyung Kim  ;  Young-Kyun Lee  ;  Yong-Chan Ha  ;  Yun Kyung Jeon  ;  Ha-Young Kim  ;  Seong Hee Ahn  ;  Seongbin Hong  ;  Sang-Yeob Lee 
 JBM : Journal of Bone Metabolism, Vol.30(4) : 311-317, 2023-11 
Journal Title
JBM : Journal of Bone Metabolism
Issue Date
Biomarkers ; Osteoporosis ; Reference values
Background: This study aimed to investigate real-world data of C-terminal telopeptide (CTX), propeptide of type I collagen (P1NP), and osteocalcin through present multicenter clinical study, and retrospectively analyze the usefulness of bone turnover markers (BTMs) in Koreans. Methods: The study focused on pre- and post-menopausal patients diagnosed with osteoporosis and excluded patients without certain test results or with test intervals of over 1 year. The demographic data and 3 BTMs (CTX, P1NP, and osteocalcin) were collected. The patients were classified by demographic characteristics and the BTM concentrations were analyzed by the group. Results: Among women with no history of fractures, the levels of P1NP (N = 2,100) were 43.544±36.902, CTX (N=1,855) were 0.373 ±0.927, and osteocalcin (N=219) were 10.81 ±20.631. Among men with no history of fractures, the levels of P1NP (N = 221) were 48.498±52.892, CTX (N = 201) were 0.370± 0.351, and osteocalcin (N = 15) were 7.868 ±10.674. Treatment with teriparatide increased the P1NP levels after 3 months in both men and women, with a 50% increase observed in women. Similarly, treatment with denosumab decreased the CTX levels after 3 months in both men and women, with a reduction of 50% observed in women. Conclusions: The results of this study can contribute to the accurate assessment of bone replacement status in Koreans. We also provide the P1NP level in the Korean population for future comparative studies with other populations. Copyright © 2023 The Korean Society for Bone and Mineral Research.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
Hong, Nam Ki(홍남기) ORCID logo https://orcid.org/0000-0002-8246-1956
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