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Frailty of Prostate Cancer Patients Receiving Androgen Deprivation Therapy: A Scoping Review

Authors
 Jeongok Park  ;  Gi Wook Ryu  ;  Hyojin Lee  ;  Young Deuk Choi  ;  Youngkyung Kim 
Citation
 WORLD JOURNAL OF MENS HEALTH, Vol.41 : e82, 2023-12 
Journal Title
WORLD JOURNAL OF MENS HEALTH
ISSN
 2287-4208 
Issue Date
2023-12
Keywords
Androgens ; Frailty ; Hormone replacement therapy ; Prostatic neoplasms
Abstract
Purpose: This study aimed to explore the existing literature on frailty experienced by patients with prostate cancer (PC) receiving

androgen deprivation therapy (ADT).

Materials and Methods: Database and manual searches were conducted to identify relevant studies published in English,

with no limitation on the year of publication, according to the Preferred Reporting Items for Systematic reviews and Meta-

Analyses extension for Scoping Reviews guidelines. Four databases—PubMed, Cochrane Library, EMBASE, and CINAHL—

were used for database searches and reference lists, related journals, and Google Scholar were used for manual searches.

Results: A total of 12 studies were analyzed for this scoping review. Of these, only 2 were intervention studies, and 1 was a

randomized controlled trial. Among the two intervention studies, the multidisciplinary intervention program, including psychological

counseling, nutritional coaching, and supervised group physical exercise did not show significant improvement in

frailty. In contrast, high-dose vitamin D supplementation significantly decreased frailty. The conceptual and operational definitions

of frailty used in each study varied, and the most used one was mainly focused on physical functions. As a result of

analyzing the other health-related variables associated with frailty in patients with PC receiving ADT, age, metastases, comorbidities,

and incident falls were related to a high frailty level. As for the physiological index, high levels of C-reactive protein,

and interleukin-6, and fibrinogen, low levels of total testosterone, lymphocyte count, and creatinine were associated with a

high level of frailty. A few studies explored the relationship between psychological and cognitive variables and frailty.

Conclusions: Further research related to frailty in patients with PC receiving ADT should be conducted, and effective interventions

to manage frailty should be developed. Additionally, research that considers not only the physical domain of frailty

but also the psychological, cognitive, and social domains needs to be conducted.
Files in This Item:
T202306600.pdf Download
DOI
10.5534/wjmh.220280
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers
Yonsei Authors
Park, Jeongok(박정옥) ORCID logo https://orcid.org/0000-0003-4978-817X
Choi, Young Deuk(최영득) ORCID logo https://orcid.org/0000-0002-8545-5797
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/197856
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