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Association between frailty and physical performance in older patients with heart failure

Authors
 Uram Jin  ;  Minjae Yoon  ;  Jaehyung Ha  ;  Seung-Hyun Lee  ;  Doeun Yun  ;  Ji-Su Kim  ;  Jaewon Oh  ;  Sungha Park  ;  Sang-Hak Lee  ;  Seok-Min Kang  ;  Chan Joo Lee 
Citation
 CLINICAL CARDIOLOGY, Vol.46(12) : 1530-1537, 2023-12 
Journal Title
CLINICAL CARDIOLOGY
ISSN
 0160-9289 
Issue Date
2023-12
MeSH
Aged ; Exercise Test ; Frailty* / complications ; Frailty* / diagnosis ; Hand Strength ; Heart Failure* / complications ; Heart Failure* / diagnosis ; Humans ; Physical Functional Performance
Keywords
6-minute walk test ; cardiopulmonary exercise test ; frailty ; heart failure
Abstract
Background: Frailty is an issue in patients with heart failure (HF). A Korean version of the frailty scale (K-FRAIL) has been developed.

Hypothesis: We aimed to analyze the relationship between the K-FRAIL scale and physical performance in patients with HF.

Methods: This study included 142 patients with HF aged ≥65 years from a single center. Muscular fitness was assessed using the handgrip test and knee extensor strength measurement. Aerobic capacity was assessed using the cardiopulmonary exercise test and 6-min walk test (6MWT). Frailty was assessed using the K-FRAIL questionnaire.

Results: Peak VO2 and 6MWT scores significantly decreased as frailty worsened, but handgrip and knee extensor strength did not. In the multivariate analysis, peak VO2 (β = -.31; p = .002) and 6MWT score (β = -.38; p < .001) showed significant inverse associations with the K-FRAIL score. Based on the receiver operating characteristic curve analysis, the cut-off values of peak VO2 (hazard ratio, 5.08; p = .023) and 6MWT (hazard ratio, 3.99; p = .020) were independent predictors of frailty.

Conclusion: In older patients with HF, physical performance correlates with the degree of frailty. The K-FRAIL scale is correlated with the peak VO2 and 6MWT.
Files in This Item:
T202400273.pdf Download
DOI
10.1002/clc.24142
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Oh, Jae Won(오재원) ORCID logo https://orcid.org/0000-0002-4585-1488
Yoon, Minjae(윤민재)
Lee, Sang Hak(이상학) ORCID logo https://orcid.org/0000-0002-4535-3745
Lee, Seunghyun(이승현)
Lee, Chan Joo(이찬주) ORCID logo https://orcid.org/0000-0002-8756-409X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/197854
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