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Clinical Characteristics and Surgical Outcomes of Obstructive Sleep Apnea Patients With Mixed Apnea Components

Authors
 Min-Seok Rha  ;  Yeonsu Jeong  ;  Chang-Hoon Kim  ;  Joo-Heon Yoon  ;  Hyung-Ju Cho 
Citation
 OTOLARYNGOLOGY-HEAD AND NECK SURGERY, Vol.168(3) : 521-527, 2023-03 
Journal Title
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
ISSN
 0194-5998 
Issue Date
2023-03
MeSH
Humans ; Male ; Oxygen ; Polysomnography ; Retrospective Studies ; Sleep Apnea, Obstructive* / complications ; Sleep Apnea, Obstructive* / surgery ; Treatment Outcome
Keywords
mixed apnea ; multilevel upper airway surgery ; obstructive sleep apnea ; surgical outcomes
Abstract
Objective: This study was aimed to investigate clinical implications of mixed apnea (MA) in patients with obstructive sleep apnea (OSA), particularly whether surgical outcomes differ between OSA patients with and without MA events.

Study design: Retrospective cohort study.

Setting: Single tertiary medical center.

Methods: Eighty-eight patients with OSA who underwent multilevel upper airway surgery were included. Patients were divided into 2 groups according to the presence of MA events: "pure group" (n = 30) and "mixed group" (n = 58). The clinical characteristics and surgical outcomes were compared between the 2 groups.

Results: The mixed group included more males (P = .020) and hypertensive patients (P = .009) and had a higher apnea-hypopnea index (AHI; P < .001) than the pure group. The surgical success rate was lower in the mixed group (29.3%) than in the pure group (73.3%; P < .001). Furthermore, the postoperative improvements in total AHI (P < .001), supine AHI (P < .001), and oxygen desaturation index (P = .006) were lower in the mixed group than in the pure group. Logistic regression analysis confirmed that the presence of MA (P = .002) was an independent predictor of poor surgical outcomes in patients with OSA.

Conclusion: OSA patients with MA showed different clinical features and poor surgical outcomes compared to those without MA. These results imply that OSA with MA components may have a distinct pathophysiology, and the presence of MA should be considered in the surgical treatment of OSA.
Full Text
https://aao-hnsfjournals.onlinelibrary.wiley.com/doi/10.1177/01945998221103800
DOI
10.1177/01945998221103800
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Hoon(김창훈) ORCID logo https://orcid.org/0000-0003-1238-6396
Rha, Min-Seok(나민석) ORCID logo https://orcid.org/0000-0003-1426-7534
Yoon, Joo Heon(윤주헌)
Cho, Hyung Ju(조형주) ORCID logo https://orcid.org/0000-0002-2851-3225
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/197575
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