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Investigating the microbiome of house dust mites in South Korea

Authors
 Myung-Hee Yi  ;  Myungjun Kim  ;  Tai-Soon Yong  ;  Ju Yeong Kim 
Citation
 FRONTIERS IN ALLERGY, Vol.4 : 1240727, 2023-08 
Journal Title
FRONTIERS IN ALLERGY
Issue Date
2023-08
Keywords
16S rDNA ; Bartonella ; Dermatophagoides farinae ; Enterococcus ; house dust mites ; microbiome
Abstract
Understanding the house dust mites (HDMs) microbiome is crucial due to its potential effects on the development of allergic diseases. In 1998, our laboratory collected Dermatophagoides farinae and D. pteronyssinus from beds in a Korean household and began cultivating these HDMs. Our laboratory has been actively investigating several topics about HDMs in recent years, including the bacterial and fungal microbiome and their interactions, as well as the impact of the HDM microbiome on airway inflammation. To study the D. farinae microbiome, we employed high-throughput sequencing of the 16S rDNA amplicons. The results revealed that the two most abundant bacteria were Enterococcus faecalis and Bartonella spp. In contrast, we found almost no bacteria in D. pteronyssinus. By inoculating bacteria to HDMs, we found that D. farinae is more susceptible to bacteria than D. pteronyssinus. This susceptibility was associated with the presence of certain fungal species in D. pteronyssinus. Additionally, we have recently made efforts to produce HDMs with reduced levels of symbiotic bacteria. We believe that standardizing and controlling the microbiome in HDMs are crucial steps for the future development and improvement of allergic immunotherapies.
Files in This Item:
T202306900.pdf Download
DOI
10.3389/falgy.2023.1240727
Appears in Collections:
1. College of Medicine (의과대학) > Others (기타) > 1. Journal Papers
Yonsei Authors
Kim, Ju Yeong(김주영) ORCID logo https://orcid.org/0000-0003-2456-6298
Yong, Tai Soon(용태순) ORCID logo https://orcid.org/0000-0002-3445-0769
Yi, Myung Hee(이명희) ORCID logo https://orcid.org/0000-0001-9537-5726
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/197337
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