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A Mechanically Resilient and Tissue‐Conformable Hydrogel with Hemostatic and Antibacterial Capabilities for Wound Care

Authors
 Jae Park  ;  Tae Young Kim  ;  Yeonju Kim  ;  Soohwan An  ;  Kyeong Seok Kim  ;  Minkyong Kang  ;  Soo A Kim  ;  Jayoung Kim  ;  Joonseok Lee  ;  Seung-Woo Cho  ;  Jungmok Seo 
Citation
 ADVANCED SCIENCE, Vol.10(30) : e2303651, 2023-10 
Journal Title
ADVANCED SCIENCE
ISSN
 * 
Issue Date
2023-10
MeSH
Animals ; Anti-Bacterial Agents / chemistry ; Anti-Bacterial Agents / pharmacology ; Hemostatics* / chemistry ; Hemostatics* / pharmacology ; Hydrogels / chemistry ; Mice ; Water ; Wound Healing
Keywords
antibacterial ; hemostasis ; hydrogels ; tissue adhesives ; wound dressing
Abstract
Hydrogels are used in wound dressings because of their tissue-like softness and biocompatibility. However, the clinical translation of hydrogels remains challenging because of their long-term stability, water swellability, and poor tissue adhesiveness. Here, tannic acid (TA) is introduced into a double network (DN) hydrogel consisting of poly(vinyl alcohol) (PVA) and poly(acrylic acid) (PAA) to realize a tough, self-healable, nonswellable, conformally tissue-adhesive, hemostatic, and antibacterial hydrogel. The TA within the DN hydrogel forms a dynamic network, enabling rapid self-healing (within 5 min) and offering effective energy dissipation for toughness and viscoelasticity. Furthermore, the hydrophobic moieties of TA provide a water-shielding effect, rendering the hydrogel nonswellable. A simple chemical modification to the hydrogel further strengthens its interfacial adhesion with tissues (shear strength of ≈31 kPa). Interestingly, the TA also can serve as an effective hemostatic (blood-clotting index of 58.40 ± 1.5) and antibacterial component, which are required for a successful wound dressing. The antibacterial effects of the hydrogel are tested against Escherichia coli and Staphylococcus aureus. Finally, the hydrogel is prepared in patch form and applied to a mouse model to test in vivo biocompatibility and hemostatic performances.
Files in This Item:
T202307302.pdf Download
DOI
10.1002/advs.202303651
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jayoung(김자영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/197175
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