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Antigen-independent IL-17A production by bystander-activated CD4+IL-1R1+ cells in patients with Multiple Sclerosis

Other Titles
 다발성 경화증에서 방관자 활성 CD4+IL-1R1+ 세포에 의한 IL-17A 생성 
Authors
 김소연 
College
 College of Medicine (의과대학) 
Department
 Others (기타) 
Degree
석사
Issue Date
2023-02
Abstract
Multiple sclerosis (MS) is a demyelinating disease caused by an autoantigen recognizing CD4+ T cells. However, IL-17A-producing CD4+ T cells that are bystander-activated by IL-1β and IL-23, and T cell receptors (TCR) independently, could contribute to experimental autoimmune encephalomyelitis. Here, we studied the differences in the frequency and function of bystander-activated CD4+ T cells in patients with MS. A significantly higher frequency of CD4+IL-1Rl+ T cells was found in memory cells than in naïve CD4+ T cells and in Th17/Th17.1 than in Th1/Th2 subtypes in both MS and healthy controls (HC). Following IL-1β and IL-23 stimulation, IL-1Rl expression was markedly increased in both memory and Th17/Th17.1 cells, and their IL-17A-production was increased after bystander activation, which was significantly higher in MS compared with HC. Our study suggests a potential role of IL-17A-producing bystander-activated CD4+IL-1Rl+ T cells in MS.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Others (기타) > 2. Thesis
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/197037
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