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Risk Factors for Surgery in Patients with Intestinal Behçet’s Disease During Anti-tumor Necrosis Factor-alpha Therapy
DC Field | Value | Language |
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dc.contributor.author | 한소정 | - |
dc.date.accessioned | 2023-12-11T02:10:00Z | - |
dc.date.available | 2023-12-11T02:10:00Z | - |
dc.date.issued | 2023-02 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196932 | - |
dc.description.abstract | Background/Aims: Behçet’s disease(BD) is a chronic inflammatory immune-mediated disease involving multiorgan systems. Gastrointestinal manifestations of BD include abdominal pain, vomiting, gastrointestinal bleeding, fistula formation, obstruction, and perforation that might require surgery. Recently, anti-TNF-α therapy has been shown to have favorable outcomes in patients with intestinal BD who are refractory to conventional therapy. This study sought to figure out the risk factors for undergoing surgery during anti-TNF-α therapy in patients with intestinal BD. Methods: In this retrospective analysis of intestinal BD patients who were treated with anti-TNF-α, we collected the baseline patient data including comorbidities, clinical, endoscopic, and radiologic characteristics, and the Disease Activity Index for Intestinal Behçet’s Disease at the time of anti-TNF-α initiation. Each potential risk factor was compared. For multivariate analysis, Cox regression was used. Results: A total of 62 patients were considered eligible for analysis, and 15 of them (24.1%) underwent surgery. In univariate analysis, the presence of extraintestinal manifestation, such as joint symptoms and ESR, were significantly associated with surgery during therapy. In multivariate analysis, drug response within 4 weeks (HR 64.59), skin and joint manifestation (HR 10.23 and HR 6.22), geographic ulcer (HR 743.97), and ESR > 42.5 mm/hr (HR 9.16) were found to be factors predictive of undergoing surgery during anti-TNF-α therapy. Conclusion: We found five risk factors predictive of surgery in patients with intestinal BD receiving anti-TNF-α therapy, which can guide physicians in selecting appropriate patients between anti-TNF-α therapy and early surgery. | - |
dc.description.statementOfResponsibility | open | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Risk Factors for Surgery in Patients with Intestinal Behçet’s Disease During Anti-tumor Necrosis Factor-alpha Therapy | - |
dc.title.alternative | 항 TNF제제 치료를 받고 있는 베체트 장염 환자에서 장절제 수술을 받을 위험 요소 분석 | - |
dc.type | Thesis | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.localId | A05438 | - |
dc.description.degree | 석사 | - |
dc.contributor.alternativeName | Han, Sojung | - |
dc.contributor.affiliatedAuthor | 한소정 | - |
dc.type.local | Thesis | - |
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