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Effect of antihypertensive medications on the risk of open-angle glaucoma

 Jihei Sara Lee  ;  Hye Ryeong Cha  ;  Hyoung Won Bae  ;  Sang Yeop Lee  ;  Wungrak Choi  ;  Seung Won Lee  ;  Chan Yun Kim 
 SCIENTIFIC REPORTS, Vol.13(1) : 16224, 2023-09 
Journal Title
Issue Date
Angiotensin Receptor Antagonists / adverse effects ; Angiotensin-Converting Enzyme Inhibitors / adverse effects ; Antihypertensive Agents / adverse effects ; Calcium Channel Blockers ; Diuretics / adverse effects ; Glaucoma, Open-Angle* / drug therapy ; Glaucoma, Open-Angle* / epidemiology ; Humans ; Hypertension* / drug therapy ; Hypertension* / epidemiology
The purpose of this study was to identify the effect of antihypertensive medication on risks of open-angle glaucoma (OAG) among patients diagnosed with hypertension (HTN). A total of 5,195 patients, who were diagnosed with HTN between January 1, 2006 and December 31, 2015, and subsequently diagnosed with OAG, were selected for analysis. For each OAG patient, 5 non-glaucomatous, hypertensive controls were matched (n = 25,975) in hypertension diagnosis date, residential area, insurance type and economic status. Antihypertensive medications were stratified into 5 types: angiotensin converting enzyme inhibitor (ACEi), angiotensin receptor blockers (ARB), calcium channel blockers (CCB), β-blockers and diuretics. Relative risks were calculated. After adjusting for age, sex, body mass index, lifestyle, comorbidities, blood pressure (BP), follow-up duration, and use of other types of antihypertensive drugs, ARB and CCB were found to slightly increase OAG risks (RR 1.1087 (95% CI 1.0293-1.1942); 1.0694 (1.0077-1.1349), respectively). Combinations of ARB with diuretics (1.0893 (1.0349-1.1466)) and CCB (1.0548 (1.0122-1.0991)) also increased OAG risks. The risks for OAG were found to increase by antihypertensive medication use, but the effects appeared to be small. Further studies are necessary to identify the associations of increased BP, medication and therapeutic effect with OAG.

© 2023. Springer Nature Limited.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chan Yun(김찬윤) ORCID logo https://orcid.org/0000-0002-8373-9999
Bae, Hyoung Won(배형원) ORCID logo https://orcid.org/0000-0002-8421-5636
Lee, Sang Yeop(이상엽) ORCID logo https://orcid.org/0000-0002-3834-7953
Lee, Jihei Sara(이지혜)
Choi, Wungrak(최웅락) ORCID logo https://orcid.org/0000-0002-3015-2502
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