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Application of error classification model using indices based on dose distribution for characteristics evaluation of multileaf collimator position errors

 Heesoon Sheen  ;  Han-Back Shin  ;  Hojae Kim  ;  Changhwan Kim  ;  Jihun Kim  ;  Jin Sung Kim  ;  Chae-Seon Hong 
 SCIENTIFIC REPORTS, Vol.13(1) : 11027, 2023-07 
Journal Title
Issue Date
Gamma Rays ; Phantoms, Imaging ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted* / methods ; Radiotherapy, Intensity-Modulated* / methods
This study aims to evaluate the specific characteristics of various multileaf collimator (MLC) position errors that are correlated with the indices using dose distribution. The dose distribution was investigated using the gamma, structural similarity, and dosiomics indices. Cases from the American Association of Physicists in Medicine Task Group 119 were planned, and systematic and random MLC position errors were simulated. The indices were obtained from distribution maps and statistically significant indices were selected. The final model was determined when all values of the area under the curve, accuracy, precision, sensitivity, and specificity were higher than 0.8 (p < 0.05). The dose-volume histogram (DVH) relative percentage difference between the error-free and error datasets was examined to investigate clinical relations. Seven multivariate predictive models were finalized. The common significant dosiomics indices (GLCM Energy and GLRLM_LRHGE) can characterize the MLC position error. In addition, the finalized logistic regression model for MLC position error prediction showed excellent performance with AUC > 0.9. Furthermore, the results of the DVH were related to dosiomics analysis in that it reflects the characteristics of the MLC position error. It was also shown that dosiomics analysis could provide important information on localized dose-distribution differences in addition to DVH information.

© 2023. The Author(s).
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1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jihun(김지훈) ORCID logo https://orcid.org/0000-0003-4856-6305
Kim, Jinsung(김진성) ORCID logo https://orcid.org/0000-0003-1415-6471
Kim, Changhwan(김창환)
Shin, Han-Back(신한백)
Hong, Chae-Seon(홍채선) ORCID logo https://orcid.org/0000-0001-9120-6132
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