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Cystoid macular edema associated with omidenepag isopropyl in a phakic eye with an implantable collamer lens: a case report

 Byung-Jin Bae  ;  Eun Min Kang  ;  Sang Yeop Lee 
 BMC OPHTHALMOLOGY, Vol.23(1) : 334, 2023-07 
Journal Title
Issue Date
Adult ; Female ; Glaucoma* / surgery ; Humans ; Lenses, Intraocular* ; Macula Lutea* ; Macular Edema* / chemically induced ; Macular Edema* / diagnosis ; Macular Edema* / drug therapy
Case report ; Cystoid macular edema ; Implantable collamer lens ; Omidenepag isopropyl ; Phakic eye
BackgroundCystoid macular edema is a known complication of omidenepag isopropyl usage. Omidenepag isopropyl is a selective prostanoid EP2 receptor agonist, and its association with macular edema has mainly been identified in pseudophakic eyes. Herein, we report a case of cystoid macular edema caused by omidenepag isopropyl use in a phakic eye with an implantable collamer lens.Case presentationA 38-year-old woman was diagnosed with left eye glaucoma and prescribed omidenepag isopropyl. She had undergone bilateral implantation of implantable collamer lenses approximately 12 years prior to the glaucoma diagnosis. After 9 months of using omidenepag isopropyl, she presented with blurred vision in the left eye; swept source optical coherence tomography revealed cystoid macular edema in this eye. Omidenepag isopropyl usage was discontinued, and bromfenac sodium hydrate was administered twice daily instead. After 2 months, the patient's visual discomfort was completely ameliorated. Additionally, an optical coherence tomography examination confirmed that the macula had normalized.ConclusionsWe report a case of cystoid macular edema development after omidenepag isopropyl use in a patient with glaucoma who had undergone bilateral implantable collamer lens implantation. This case shows that the possibility of cystoid macular edema occurrence should be considered when omidenepag isopropyl is used, even in phakic eyes, after the insertion of implantable collamer lenses.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Sang Yeop(이상엽) ORCID logo https://orcid.org/0000-0002-3834-7953
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