42 144

Cited 1 times in

Inhibition of protein arginine deiminase II suppresses retinoblastoma in orthotopic transplantation in mice

Authors
 Sojin Kim  ;  Yong Keun Song  ;  Chang Sik Cho  ;  Hyo Jung Kim  ;  Sungsoon Fang  ;  Dong Hyun Jo  ;  Hyunkyung Kim 
Citation
 ONCOLOGY REPORTS, Vol.50(1) : 146, 2023-07 
Journal Title
ONCOLOGY REPORTS
ISSN
 1021-335X 
Issue Date
2023-07
MeSH
Animals OR Disease Models, Animal OR Humans OR Mice OR Mutation OR Protein-Arginine Deiminases / genetics OR Protein-Arginine Deiminases / metabolism OR Retinal Neoplasms* / drug therapy OR Retinal Neoplasms* / genetics OR Retinoblastoma* / drug therapy OR Retinoblastoma* / genetics OR Retinoblastoma* / pathology
Keywords
AKT phosphorylation ; BB‑Cl‑amidine ; E2 factor ; protein arginine deiminase II ; retinoblastoma
Abstract
Chemotherapies are used for treating retinoblastoma; however, numerous patients suffer from recurrence or symptoms due to chemotherapy, which emphasizes the need for alternative therapeutic strategies. The present study demonstrated that protein arginine deiminase II (PADI2) was highly expressed in human and mouse retinoblastoma tissues due to the overexpression of E2 factor (E2F). By inhibiting PADI2 activity, the expression of phosphorylated AKT was reduced, and cleaved poly (ADP-ribose) polymerase level was increased, leading to induced apoptosis. Similar results were obtained in orthotopic mouse models with reduced tumor volumes. In addition, BB-Cl-amidine showed low toxicity in vivo. These results suggested that PADI2 inhibition has potential clinical translation. Furthermore, the present study highlights the potential of epigenetic approaches to target RB1-deficient mutations at the molecular level. The current findings provide new insights into the importance of retinoblastoma intervention by managing PADI2 activity according to the treatment of specific inhibitors and depletion approaches in vitro and in orthotopic mouse models.
Files in This Item:
T202304185.pdf Download
DOI
10.3892/or.2023.8583
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Fang, Sungsoon(황성순) ORCID logo https://orcid.org/0000-0003-0201-5567
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/196142
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links