Cited 3 times in
Comparison of Programmed Cell Death Ligand 1 Status between Core Needle Biopsy and Surgical Specimens of Triple-Negative Breast Cancer
DC Field | Value | Language |
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dc.contributor.author | 김지형 | - |
dc.contributor.author | 남지해 | - |
dc.contributor.author | 배숭준 | - |
dc.contributor.author | 안성귀 | - |
dc.contributor.author | 은나래 | - |
dc.contributor.author | 이양규 | - |
dc.contributor.author | 정준 | - |
dc.contributor.author | 차윤진 | - |
dc.date.accessioned | 2023-08-09T07:03:15Z | - |
dc.date.available | 2023-08-09T07:03:15Z | - |
dc.date.issued | 2023-08 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196041 | - |
dc.description.abstract | Purpose: Pembrolizumab is currently used to treat advanced triple-negative breast cancer (TNBC) and high-risk early TNBC with neoadjuvant chemotherapy (NAC). The tumor-infiltrating lymphocyte (TIL) level and programmed cell death ligand 1 (PD-L1) status are predictors of response to NAC and immune checkpoint inhibitor treatment. We aimed to investigate whether the PD-L1 status in core needle biopsies (CNBs) could represent the whole tumor in TNBC. Materials and methods: A total of 49 patients diagnosed with TNBC who received upfront surgery without NAC between January 2018 and March 2021 were included. The PD-L1 expression (SP142 and 22C3 clones) and TIL were evaluated in paired CNBs and resected specimens. The concordance PD-L1 status and TIL levels between CNBs and resected specimens were analyzed. Results: PD-L1 positivity was more frequently observed in resected specimens. The overall reliability of TIL level in the CNB was good [intraclass correlation coefficient (ICC)=0.847, p<0.001]. The agreements of PD-L1 status were good and fair, respectively (SP142, κ=0.503, p<0.001; 22C3, κ=0.380, p=0.010). As the core number of CNB increased, the reliability and agreement also improved, especially from five tumor cores (TIL, ICC=0.911, p<0.001; PD-L1 [22C3], κ=0.750, p=0.028). Regarding PD-L1 (SP142), no further improvement was observed with ≥5 tumor cores (κ=0.600, p=0.058). Conclusion: CNBs with ≥5 tumor cores were sufficient to represent the TIL level and PD-L1 (22C3) status in TNBC. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Apoptosis | - |
dc.subject.MESH | B7-H1 Antigen | - |
dc.subject.MESH | Biopsy, Large-Core Needle | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Ligands | - |
dc.subject.MESH | Reproducibility of Results | - |
dc.subject.MESH | Triple Negative Breast Neoplasms* | - |
dc.title | Comparison of Programmed Cell Death Ligand 1 Status between Core Needle Biopsy and Surgical Specimens of Triple-Negative Breast Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Hyungwook Choi | - |
dc.contributor.googleauthor | Sung Gwe Ahn | - |
dc.contributor.googleauthor | Soong Joon Bae | - |
dc.contributor.googleauthor | Jee Hung Kim | - |
dc.contributor.googleauthor | Na Lae Eun | - |
dc.contributor.googleauthor | Yangkyu Lee | - |
dc.contributor.googleauthor | Ji Hae Nahm | - |
dc.contributor.googleauthor | Joon Jeong | - |
dc.contributor.googleauthor | Yoon Jin Cha | - |
dc.identifier.doi | 10.3349/ymj.2023.0090 | - |
dc.contributor.localId | A00999 | - |
dc.contributor.localId | A05120 | - |
dc.contributor.localId | A05345 | - |
dc.contributor.localId | A02231 | - |
dc.contributor.localId | A04778 | - |
dc.contributor.localId | A06080 | - |
dc.contributor.localId | A03727 | - |
dc.contributor.localId | A04001 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 37488704 | - |
dc.subject.keyword | PD-L1 | - |
dc.subject.keyword | Triple-negative breast cancer | - |
dc.subject.keyword | immunohistochemistry | - |
dc.subject.keyword | pathology | - |
dc.subject.keyword | tumor-infiltrating lymphocytes | - |
dc.contributor.alternativeName | Kim, Jee Hung | - |
dc.contributor.affiliatedAuthor | 김지형 | - |
dc.contributor.affiliatedAuthor | 남지해 | - |
dc.contributor.affiliatedAuthor | 배숭준 | - |
dc.contributor.affiliatedAuthor | 안성귀 | - |
dc.contributor.affiliatedAuthor | 은나래 | - |
dc.contributor.affiliatedAuthor | 이양규 | - |
dc.contributor.affiliatedAuthor | 정준 | - |
dc.contributor.affiliatedAuthor | 차윤진 | - |
dc.citation.volume | 64 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 518 | - |
dc.citation.endPage | 525 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.64(8) : 518-525, 2023-08 | - |
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