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The effects of long-term cumulative HbA1c exposure on the development and onset time of dementia in the patients with type 2 diabetes mellitus: Hospital based retrospective study (2005-2021)

Authors
 Sunyoung Cho  ;  Choon Ok Kim  ;  Bong-Soo Cha  ;  Eosu Kim  ;  Chung Mo Nam  ;  Min-Gul Kim  ;  Min Soo Park 
Citation
 DIABETES RESEARCH AND CLINICAL PRACTICE, Vol.201 : 110721, 2023-07 
Journal Title
DIABETES RESEARCH AND CLINICAL PRACTICE
ISSN
 0168-8227 
Issue Date
2023-07
MeSH
Blood Glucose ; Dementia* / epidemiology ; Dementia* / etiology ; Diabetes Mellitus, Type 2* / complications ; Diabetes Mellitus, Type 2* / epidemiology ; Glycated Hemoglobin ; Humans ; Hyperglycemia* / complications ; Retrospective Studies
Keywords
Cumulative HbA1c ; Cumulative effect ; Dementia ; Long-term glycemic exposure ; Type 2 diabetes mellitus ; mean HbA1c over time
Abstract
Aims: We examined cumulative effects of long-term glycemic exposure in patients with type 2 diabetes mellitus (T2DM) on the development of dementia.

Methods: The study involved 20,487 records of patients with T2DM identified in the electronic medical record at Severance Hospital, Korea. Cumulative HbA1c (AUCHbA1c) and mean HbA1c over time (HbA1cavg) as measures of long-term glycemic exposure were compared for the development of dementia and the time to dementia.

Results: AUCHbA1c and HbA1cavg were significantly higher in patients who later developed dementia than in those who did not (AUCHbA1c: 56.2 ± 26.4 vs. 52.1 ± 26.1 %Year; HbA1cavg: 7.3 ± 1.0 vs. 7.0 ± 1.0%). Odds ratio of dementia increased when HbA1cavg was 7.2% (55 mmol/mol) or above, and when AUCHbA1c was 42 %Year (e.g., HbA1c 7.0% maintained for 6 years) or above. Among those who developed dementia, as HbA1cavg increased, the time to dementia onset decreased (β = -380.6 days, 95% confidence interval [CI]: -416.2 to -345.0).

Conclusions: Our results indicate poorly controlled T2DM was associated with an increased risk of developing dementia, as measured by AUCHbA1c and HbA1cavg. Higher cumulative glycemic exposure may lead to developing dementia in a shorter time.
Full Text
https://www.sciencedirect.com/science/article/pii/S0168822723004849
DOI
10.1016/j.diabres.2023.110721
Appears in Collections:
6. Others (기타) > Dept. of Clinical Pharmacology (임상시험센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eosu(김어수) ORCID logo https://orcid.org/0000-0001-9472-9465
Kim, Choon Ok(김춘옥) ORCID logo https://orcid.org/0000-0002-2319-1108
Nam, Chung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Park, Min Soo(박민수) ORCID logo https://orcid.org/0000-0002-4395-9938
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/195974
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