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Effect of S267F variant of NTCP on the patients with chronic hepatitis B

Authors
 Hye Won Lee  ;  Hye Jung Park  ;  Bora Jin  ;  Mehrangiz Dezhbord  ;  Do Young Kim  ;  Kwang-Hyub Han  ;  Wang-Shick Ryu  ;  Seungtaek Kim  ;  Sang Hoon Ahn 
Citation
 SCIENTIFIC REPORTS, Vol.7(1) : 17634, 2017-12 
Journal Title
SCIENTIFIC REPORTS
Issue Date
2017-12
MeSH
Amino Acid Substitution / genetics* ; Carcinoma, Hepatocellular / genetics ; Carcinoma, Hepatocellular / virology ; Disease Progression ; Female ; Hepatitis B virus / metabolism ; Hepatitis B, Chronic / transmission* ; Hepatitis B, Chronic / virology ; Humans ; Liver Cirrhosis / genetics ; Liver Cirrhosis / virology ; Liver Neoplasms / genetics ; Liver Neoplasms / virology ; Male ; Middle Aged ; Organic Anion Transporters, Sodium-Dependent / genetics* ; Polymorphism, Single Nucleotide / genetics ; Receptors, Virus / genetics* ; Republic of Korea ; Symporters / genetics* ; Virus Internalization*
Abstract
Sodium taurocholate cotransporting polypeptide (NTCP) was identified as an entry receptor for hepatitis B virus (HBV) infection. The substitution of serine at position 267 of NTCP with phenylalanine (S267F) is an Asian-specific variation that hampers HBV entry in vitro. In this study, we aimed to evaluate the prevalence of S267F polymorphism in Korean patients with chronic hepatitis B (CHB) and its association with disease progression and potential viral evolution in the preS1 domain of HBV. We found that the frequency of the S267F variant of NTCP in CHB patients and controls was 2.7% and 5.7% (P = 0.031), respectively, and that those who had S267F variant were less susceptible to chronic HBV infection. The frequency of the S267F variant in CHB, cirrhosis and hepatocellular carcinoma (HCC) patients was 3.3%, 0.9%, and 3.5%, respectively. Thus, the S267F variant correlated significantly with a lower risk for cirrhosis (P = 0.036). Sequencing preS1 domain of HBV from the patients who had S267F variant revealed no significant sequence change compared to the wild type. In conclusion, the S267F variant of NTCP is clinically associated with a lower risk of chronic HBV infection and cirrhosis development, which implicates suppressing HBV entry could reduce the disease burden.
Files in This Item:
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DOI
10.1038/s41598-017-17959-x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영)
Kim, Seung Taek(김승택)
Park, Hye Jung(박혜정) ORCID logo https://orcid.org/0000-0002-1862-1003
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Lee, Hye Won(이혜원) ORCID logo https://orcid.org/0000-0002-3552-3560
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/195886
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