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Urinary phthalate metabolites over the first 15months of life and risk assessment - CHECK cohort study

Authors
 Sunmi Kim  ;  Jangwoo Lee  ;  Jeongim Park  ;  Hai-Joong Kim  ;  Geum Joon Cho  ;  Gun-Ha Kim  ;  So-Hee Eun  ;  Jeong Jae Lee  ;  Gyuyeon Choi  ;  Eunsook Suh  ;  Sooran Choi  ;  Sungjoo Kim  ;  Sung Koo Kim  ;  Young Don Kim  ;  Su Young Kim  ;  Seunghyo Kim  ;  Soyong Eom  ;  Hyo-Bang Moon  ;  Sungkyoon Kim  ;  Kyungho Choi 
Citation
 SCIENCE OF THE TOTAL ENVIRONMENT, Vol.607-608 : 881-887, 2017-12 
Journal Title
SCIENCE OF THE TOTAL ENVIRONMENT
ISSN
 0048-9697 
Issue Date
2017-12
MeSH
Cohort Studies ; Diethylhexyl Phthalate ; Environmental Exposure / adverse effects* ; Environmental Pollutants / urine* ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Phthalic Acids / urine* ; Republic of Korea ; Risk Assessment
Keywords
Infant ; Phthalates ; Repeated measurement ; Trend ; Urine ; Within-subject variation
Abstract
Phthalates are important group of endocrine disruptors. Infants and young children are susceptible to phthalate exposure. However, information on the phthalate exposure during the early stages of life is very limited. This study was conducted to understand the temporal trend of exposure to major phthalates among infants of Korea during the first 15months after birth, and to estimate associated risks. A total of 286 urine samples were collected from 171 children at 3, 9, 12, or 15months of age, with 77 children sampled for two or more times. Four phthalates, i.e., di(2-ethylhexyl) phthalate (DEHP), di-isobutyl phthalate (DiBP), di-n-butyl phthalate (DnBP), and diethyl phthalate (DEP) were chosen, and their major metabolites were analyzed in the urine. The DEHP metabolites were detected in 100% of the urine samples at relatively higher levels compared to those reported in other countries. The levels of mono-ethyl phthalate (MEP) were generally lower. Urinary concentrations of most phthalate metabolites, especially DEHP metabolites, increased as children grew older. Intra-class correlation coefficients (ICCs) calculated for DEHP metabolites over time were high (0.7-0.8), suggesting persistence of consistent exposure sources during this sensitive period of life. Hazard quotient (HQ) and hazard index (HI) were calculated from daily intake estimates divided by recommended toxicity thresholds. Among the study population, 4, 16, and 26% of the children showed HI >1 at 9, 12, and 15months of age, respectively. DEHP exposure explained most of the risk estimates. Considering vulnerability of young children to endocrine disruption, efforts to identify sources of exposure and to develop appropriate mitigation options are warranted.
Full Text
https://www.sciencedirect.com/science/article/pii/S0048969717316649
DOI
10.1016/j.scitotenv.2017.06.244
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
Yonsei Authors
Eom, So Yong(엄소용)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/195883
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