Cited 17 times in
Synergistic inhibition effect of TNIK inhibitor KY-05009 and receptor tyrosine kinase inhibitor dovitinib on IL-6-induced proliferation and Wnt signaling pathway in human multiple myeloma cells
DC Field | Value | Language |
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dc.date.accessioned | 2023-08-09T02:47:59Z | - |
dc.date.available | 2023-08-09T02:47:59Z | - |
dc.date.issued | 2017-06 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195847 | - |
dc.description.abstract | Multiple myeloma is a fetal form of plasma cell malignancy characterized by abnormal clonal proliferation of plasma cells. Especially, the canonical Wnt signaling pathway mediated by β-catenin is activated in multiple myeloma cells, stimulating their proliferation. Here, we investigated the relationship between interleukin-6-induced proliferation of multiple myeloma cells and Traf2- and Nck-interacting kinase (TNIK) expression in Wnt signaling. Interleukin-6 increased the proliferation of multiple myeloma cells and TNIK mRNA and protein expression. In addition, we examined the effect on TNIK of TNIK inhibitor KY-05009 and receptor tyrosine kinase inhibitor dovitinib and whether inhibition of TNIK suppresses the interleukin-6-induced proliferation of multiple myeloma cells. KY-05009 and dovitinib synergistically inhibited interleukin-6-stimulated proliferation and induced apoptosis through the inhibition of Wnt signaling in MM cells. Our results provide crucial information that TNIK is involved in the interleukin-6-dependent proliferation of multiple myeloma cells and inhibition of Wnt signaling involving TNIK could be a therapeutic strategy for the treatment of interleukin-6-dependent multiple myeloma. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Impact Journals | - |
dc.relation.isPartOf | ONCOTARGET | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aniline Compounds / pharmacology* | - |
dc.subject.MESH | Apoptosis / drug effects | - |
dc.subject.MESH | Apoptosis / genetics | - |
dc.subject.MESH | Benzimidazoles / pharmacology* | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Proliferation / drug effects* | - |
dc.subject.MESH | Cell Proliferation / genetics | - |
dc.subject.MESH | Cell Survival / drug effects | - |
dc.subject.MESH | Cell Survival / genetics | - |
dc.subject.MESH | Drug Synergism | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic / drug effects | - |
dc.subject.MESH | Germinal Center Kinases | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interleukin-6 / pharmacology* | - |
dc.subject.MESH | Multiple Myeloma / genetics | - |
dc.subject.MESH | Multiple Myeloma / metabolism | - |
dc.subject.MESH | Multiple Myeloma / pathology | - |
dc.subject.MESH | Protein Kinase Inhibitors / pharmacology | - |
dc.subject.MESH | Protein Serine-Threonine Kinases / antagonists & inhibitors* | - |
dc.subject.MESH | Protein Serine-Threonine Kinases / genetics | - |
dc.subject.MESH | Protein Serine-Threonine Kinases / metabolism | - |
dc.subject.MESH | Quinolones / pharmacology* | - |
dc.subject.MESH | Thiazoles / pharmacology* | - |
dc.subject.MESH | Wnt Signaling Pathway / drug effects* | - |
dc.subject.MESH | Wnt Signaling Pathway / genetics | - |
dc.subject.MESH | beta Catenin / genetics | - |
dc.subject.MESH | beta Catenin / metabolism | - |
dc.title | Synergistic inhibition effect of TNIK inhibitor KY-05009 and receptor tyrosine kinase inhibitor dovitinib on IL-6-induced proliferation and Wnt signaling pathway in human multiple myeloma cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Others | - |
dc.contributor.googleauthor | Yura Lee | - |
dc.contributor.googleauthor | Jung-Il Jung | - |
dc.contributor.googleauthor | Kyeong-Yong Park | - |
dc.contributor.googleauthor | Soon Ae Kim | - |
dc.contributor.googleauthor | Jiyeon Kim | - |
dc.identifier.doi | 10.18632/oncotarget.17056 | - |
dc.relation.journalcode | J02421 | - |
dc.identifier.eissn | 1949-2553 | - |
dc.identifier.pmid | 28467797 | - |
dc.subject.keyword | IL-6 | - |
dc.subject.keyword | KY-05009 | - |
dc.subject.keyword | TNIK | - |
dc.subject.keyword | Wnt signaling | - |
dc.subject.keyword | multiple myeloma | - |
dc.citation.volume | 8 | - |
dc.citation.number | 25 | - |
dc.citation.startPage | 41091 | - |
dc.citation.endPage | 41101 | - |
dc.identifier.bibliographicCitation | ONCOTARGET, Vol.8(25) : 41091-41101, 2017-06 | - |
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