Cited 36 times in
Diffusion-Weighted MR Enterography to Monitor Bowel Inflammation after Medical Therapy in Crohn's Disease: A Prospective Longitudinal Study
DC Field | Value | Language |
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dc.contributor.author | 한경화 | - |
dc.date.accessioned | 2023-08-09T02:46:27Z | - |
dc.date.available | 2023-08-09T02:46:27Z | - |
dc.date.issued | 2017-02 | - |
dc.identifier.issn | 1229-6929 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195819 | - |
dc.description.abstract | Objective: To prospectively evaluate the performance of diffusion-weighted imaging (DWI) to monitor bowel inflammation after medical therapy for Crohn's disease (CD). Materials and methods: Before and following 1-2 years of medical therapy, between October 2012 and May 2015, 18 randomly selected adult CD patients (male:female, 13:5; mean age ± SD, 25.8 ± 7.9 years at the time of enrollment) prospectively underwent MR enterography (MRE) including DWI (b = 900 s/mm2) and ileocolonoscopy. Thirty-seven prospectively defined index lesions (one contiguous endoscopy-confirmed inflamed area chosen from each inflamed anatomical bowel segment; 1-4 index lesions per patient; median, 2 lesions) were assessed on pre- and post-treatment MRE and endoscopy. Visual assessment of treatment responses on DWI in 4 categories including complete remission and reduced, unchanged or increased inflammation, and measurements of changes in apparent diffusion coefficient (ΔADC), i.e., pre-treatment-post-treatment, were performed by 2 independent readers. Endoscopic findings and CD MRI activity index (CDMI) obtained using conventional MRE served as reference standards. Results: ΔADC significantly differed between improved (i.e., complete remission and reduced inflammation) and unimproved (i.e., unchanged or increased inflammation) lesions: mean ± SD (× 10-3 mm2/s) of -0.65 ± 0.58 vs. 0.06 ± 0.15 for reader 1 (p = 0.022) and -0.68 ± 0.56 vs. 0.10 ± 0.26 for reader 2 (p = 0.025). DWI accuracy for diagnosing complete remission or improved inflammation ranged from 76% (28/37) to 84% (31/37). A significant negative correlation was noted between ΔADC and ΔCDMI for both readers with correlation coefficients of -0.438 and -0.461, respectively (p < 0.05). Conclusion: DWI is potentially a feasible tool to monitor quantitatively and qualitatively bowel inflammation of CD after medical treatment. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Society of Radiology | - |
dc.relation.isPartOf | KOREAN JOURNAL OF RADIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Anti-Inflammatory Agents, Non-Steroidal / therapeutic use | - |
dc.subject.MESH | Crohn Disease / diagnostic imaging | - |
dc.subject.MESH | Crohn Disease / drug therapy | - |
dc.subject.MESH | Crohn Disease / pathology* | - |
dc.subject.MESH | Diffusion Magnetic Resonance Imaging* | - |
dc.subject.MESH | Endoscopy, Gastrointestinal | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunosuppressive Agents / therapeutic use | - |
dc.subject.MESH | Inflammation / diagnostic imaging | - |
dc.subject.MESH | Inflammation / pathology | - |
dc.subject.MESH | Infliximab / therapeutic use | - |
dc.subject.MESH | Intestine, Large / diagnostic imaging | - |
dc.subject.MESH | Intestine, Large / pathology | - |
dc.subject.MESH | Longitudinal Studies | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Young Adult | - |
dc.title | Diffusion-Weighted MR Enterography to Monitor Bowel Inflammation after Medical Therapy in Crohn's Disease: A Prospective Longitudinal Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Research Institute (부설연구소) | - |
dc.contributor.googleauthor | Jimi Huh | - |
dc.contributor.googleauthor | Kyung Jo Kim | - |
dc.contributor.googleauthor | Seong Ho Park | - |
dc.contributor.googleauthor | So Hyun Park | - |
dc.contributor.googleauthor | Suk-Kyun Yang | - |
dc.contributor.googleauthor | Byong Duk Ye | - |
dc.contributor.googleauthor | Sang Hyoung Park | - |
dc.contributor.googleauthor | Kyunghwa Han | - |
dc.contributor.googleauthor | Ah Young Kim | - |
dc.identifier.doi | 10.3348/kjr.2017.18.1.162 | - |
dc.contributor.localId | A04267 | - |
dc.relation.journalcode | J02884 | - |
dc.identifier.eissn | 2005-8330 | - |
dc.identifier.pmid | 28096726 | - |
dc.subject.keyword | Crohn | - |
dc.subject.keyword | Crohn's | - |
dc.subject.keyword | Diffusion | - |
dc.subject.keyword | Diffusion-weighted | - |
dc.subject.keyword | Follow-up | - |
dc.subject.keyword | Longitudinal | - |
dc.subject.keyword | Magnetic resonance | - |
dc.subject.keyword | Magnetic resonance enterography | - |
dc.subject.keyword | Monitoring | - |
dc.contributor.alternativeName | Han, Kyung Hwa | - |
dc.contributor.affiliatedAuthor | 한경화 | - |
dc.citation.volume | 18 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 162 | - |
dc.citation.endPage | 172 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF RADIOLOGY, Vol.18(1) : 162-172, 2017-02 | - |
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