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Association of Condylar Bone Quality with TMJ Osteoarthritis

Authors
 J Shi  ;  S Lee  ;  H C Pan  ;  A Mohammad  ;  A Lin  ;  W Guo  ;  E Chen  ;  A Ahn  ;  J Li  ;  K Ting  ;  J H Kwak 
Citation
 JOURNAL OF DENTAL RESEARCH, Vol.96(8) : 888-894, 2017-07 
Journal Title
JOURNAL OF DENTAL RESEARCH
ISSN
 0022-0345 
Issue Date
2017-07
MeSH
Aged ; Bone Density* ; China ; Cone-Beam Computed Tomography ; Cross-Sectional Studies ; Female ; Humans ; Mandibular Condyle / diagnostic imaging* ; Mandibular Condyle / pathology* ; Middle Aged ; Osteoarthritis / diagnostic imaging* ; Osteoarthritis / pathology* ; Postmenopause ; Retrospective Studies ; Temporomandibular Joint Disorders / diagnostic imaging* ; Temporomandibular Joint Disorders / pathology*
Keywords
bone volume ; cone beam computed tomography ; cross-sectional study ; mandibular condyle ; micro-computed tomography ; multivariate analysis
Abstract
The etiology and treatment of temporomandibular joint (TMJ) osteoarthritis (TMJOA) remain complex and unclear. Based on clinical observations, we hypothesized that low condylar bone quality is significantly correlated with TMJOA and explored this association in a cross-sectional study with human patients. A total of 254 postmenopausal female participants were included in this study. Radiographic findings from cone beam computed tomography (CBCT) and clinical symptoms were used to classify each TMJ data sample as healthy control ( n = 124) or TMJOA ( n = 130). Condylar bone mineral density (BMD) (computed tomography Hounsfield unit [CT HU]) and bone volume fraction (BV/TV) were measured and modeled as predictors of healthy control versus TMJOA status in multilevel logistic regression analyses. Both CT HU (adjusted odds ratio [AOR] = 0.9989, interquartile odds ratio [IOR] = 0.4206) and BV/TV (AOR= 0.8096, IOR = 0.1769) were negatively associated with TMJOA ( P = 0.049, 0.011, respectively). To assess the diagnostic performance of CT HU and BV/TV for identification of TMJOA, receiver operating characteristic (ROC) curves were plotted. The estimated areas under the curve (AUC) were 0.6622 for BV/TV alone, 0.6074 for CT HU alone, and 0.7136 for CT HU and BV/TV together. The model incorporating CT HU and BV/TV together had a significantly higher AUC than the models using BV/TV alone ( P = 0.038) or HU alone ( P = 0.021). In conclusion, we found that low condylar bone quality was significantly correlated with TMJOA development and that condylar CT HU and BV/TV can be used together as a potential diagnostic tool for TMJOA. Careful clinical evaluation of the condyle coupled with appropriate radiographic interpretation would thus be critical for the early detection of TMJOA.
Files in This Item:
T992017277.pdf Download
DOI
10.1177/0022034517707515
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/195758
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