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Trends in CD4 cell count response to first-line antiretroviral treatment in HIV-positive patients from Asia, 2003-2013: TREAT Asia HIV Observational Database Low Intensity Transfer

Authors
 Nicole L De La Mata  ;  Penh S Ly  ;  Oon T Ng  ;  Kinh V Nguyen  ;  Tuti P Merati  ;  Thuy T Pham  ;  Man P Lee  ;  Jun Y Choi  ;  Annette H Sohn  ;  Matthew G Law  ;  Nagalingeswaran Kumarasamy 
Citation
 INTERNATIONAL JOURNAL OF STD & AIDS, Vol.28(13) : 1282-1291, 2017-11 
Journal Title
INTERNATIONAL JOURNAL OF STD & AIDS
ISSN
 0956-4624 
Issue Date
2017-11
MeSH
Adult ; Anti-HIV Agents / administration & dosage ; Anti-HIV Agents / therapeutic use* ; Antiretroviral Therapy, Highly Active / methods* ; Antiretroviral Therapy, Highly Active / trends ; Asia ; CD4 Lymphocyte Count / statistics & numerical data* ; Drug Administration Schedule ; Female ; HIV Infections / drug therapy* ; HIV Infections / immunology ; HIV Infections / virology ; Humans ; Male ; Middle Aged ; Time Factors ; Viral Load
Keywords
Asia ; CD4 trends ; HIV ; antiretroviral treatment ; epidemiology ; immunological response
Abstract
Antiretroviral treatment (ART) guidelines have changed over the past decade, recommending earlier initiation and more tolerable regimens. The study objective was to examine the CD4 response to ART, depending on the year of ART initiation, in HIV-positive patients in the Asia-Pacific. We included HIV-positive adult patients who initiated ART between 2003 and 2013 in our regional cohort from eight urban referral centres in seven countries within Asia. We used mixed-effects linear regression models to evaluate differences in CD4 response by year of ART initiation during 36 months of follow-up, adjusted a priori for other covariates. Overall, 16,962 patients were included. Patients initiating in 2006-9 and 2010-13 had an estimated mean CD4 cell count increase of 8 and 15 cells/µl, respectively, at any given time during the 36-month follow-up, compared to those in 2003-5. The median CD4 cell count at ART initiation also increased from 96 cells/µl in 2003-5 to 173 cells/µl in 2010-13. Our results suggest that the CD4 response to ART is modestly higher for those initiating ART in more recent years. Moreover, fewer patients are presenting with lower absolute CD4 cell counts over time. This is likely to reduce their risk of opportunistic infections and future non-AIDS defining cancers.
Files in This Item:
T999201779.pdf Download
DOI
10.1177/0956462417699538
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/195730
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