Cited 26 times in
Acidification of stratum corneum prevents the progression from atopic dermatitis to respiratory allergy
DC Field | Value | Language |
---|---|---|
dc.date.accessioned | 2023-08-09T02:38:08Z | - |
dc.date.available | 2023-08-09T02:38:08Z | - |
dc.date.issued | 2017-01 | - |
dc.identifier.issn | 0906-6705 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195697 | - |
dc.description.abstract | The presence of congenitally impaired skin barrier followed by atopic dermatitis (AD) is an initial step in the atopic march. The maintenance of acidic pH in the stratum corneum (SC) has been suggested as a therapeutic or preventive strategy for barrier impairment caused by skin inflammation. To determine whether an AD murine model, flaky tail mice, with inherited filaggrin deficiency could develop airway inflammation by repeated topical application followed by nasal inhalation of house dust mite (HDM) antigen (defined as a novel "atopic march animal model"), and whether maintenance of an acidic SC environment by continuous application of acidic cream could interrupt the following atopic march. During the course of HDM treatment, acidic cream (pH2.8) or neutral cream (pH7.4) was applied to flaky tail mice twice daily. Repeated applications and inhalations of HDM to flaky tail mice induced AD skin lesions followed by respiratory allergies. Maintenance of SC acidity inhibited the occurrence of respiratory allergic inflammation as well as AD-like skin lesions. Collectively, a novel atopic march model could be developed by repeated epicutaneous and nasal applications of HDM to flaky tail mice, and that the acidification of SC could prevent the atopic march from AD to respiratory allergy. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Munksgaard | - |
dc.relation.isPartOf | EXPERIMENTAL DERMATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Administration, Cutaneous | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antigens, Dermatophagoides / toxicity | - |
dc.subject.MESH | Cytokines / blood | - |
dc.subject.MESH | Dermatitis, Atopic / complications | - |
dc.subject.MESH | Dermatitis, Atopic / genetics | - |
dc.subject.MESH | Dermatitis, Atopic / prevention & control* | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Epidermis / chemistry* | - |
dc.subject.MESH | Epidermis / metabolism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Filaggrin Proteins | - |
dc.subject.MESH | Hydrogen-Ion Concentration | - |
dc.subject.MESH | Immunoglobulin E / blood | - |
dc.subject.MESH | Inhalation Exposure / adverse effects | - |
dc.subject.MESH | Intermediate Filament Proteins / deficiency | - |
dc.subject.MESH | Intermediate Filament Proteins / genetics* | - |
dc.subject.MESH | Membrane Proteins / metabolism | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Protein Precursors / metabolism | - |
dc.subject.MESH | Respiratory Hypersensitivity / etiology* | - |
dc.subject.MESH | Respiratory Hypersensitivity / prevention & control* | - |
dc.subject.MESH | Skin Cream / chemistry | - |
dc.subject.MESH | Skin Cream / therapeutic use* | - |
dc.subject.MESH | Thymic Stromal Lymphopoietin | - |
dc.title | Acidification of stratum corneum prevents the progression from atopic dermatitis to respiratory allergy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학교실) | - |
dc.contributor.googleauthor | Hae-Jin Lee | - |
dc.contributor.googleauthor | Noo Ri Lee | - |
dc.contributor.googleauthor | Bo-Kyung Kim | - |
dc.contributor.googleauthor | Minyoung Jung | - |
dc.contributor.googleauthor | Dong Hye Kim | - |
dc.contributor.googleauthor | Catharina S Moniaga | - |
dc.contributor.googleauthor | Kenji Kabashima | - |
dc.contributor.googleauthor | Eung Ho Choi | - |
dc.identifier.doi | 10.1111/exd.13144 | - |
dc.relation.journalcode | J00866 | - |
dc.identifier.eissn | 1600-0625 | - |
dc.identifier.pmid | 27376923 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/exd.13144 | - |
dc.subject.keyword | acidification | - |
dc.subject.keyword | atopic dermatitis | - |
dc.subject.keyword | atopic march | - |
dc.subject.keyword | flaky tail mice | - |
dc.subject.keyword | respiratory allergy | - |
dc.citation.volume | 26 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 66 | - |
dc.citation.endPage | 72 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL DERMATOLOGY, Vol.26(1) : 66-72, 2017-01 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.