133 208

Cited 0 times in

Activated carbon nanofiber nanoparticles incorporated electrospun polycaprolactone scaffolds to promote fibroblast behaviors for application to skin tissue engineering

Authors
 Sangmun Choi  ;  Iruthayapandi Selestin Raja  ;  Aravindha Raja Selvaraj  ;  Moon Sung Kang  ;  Tae-Eon Park  ;  Ki Su Kim  ;  Suong-Hyu Hyon  ;  Dong-Wook Han & Jong-Chul Park 
Citation
 ADVANCED COMPOSITES AND HYBRID MATERIALS, Vol.6(1) : 24, 2023-02 
Journal Title
 ADVANCED COMPOSITES AND HYBRID MATERIALS 
Issue Date
2023-02
Keywords
Electrospun nanofiber ; Activated carbon nanofiber nanoparticles ; Polycaprolactone ; Skin tissue engineering
Abstract
The most widely used one-dimensional (1D) carbonaceous nanomaterials in tissue engineering are carbon nanotubes, either single or multiwalled. Other forms of 1D nanomaterials, such as carbon nanowires and carbon nanofibers, have been less explored for biomedical applications. Herein, we synthesized 1D-activated carbon nanofiber nanoparticles (ACNF NPs) from the polyacrylonitrile electrospun nanofibers by continuous processes like stabilization, alkali treatment, calcination, and grinding. Two different sets of ACNF NPs-containing electrospun polycaprolactone (PCL) nanofiber mats, viz. surface-modified NP-deposited mats (ACNF@PCL) and NP-incorporated mats (ACNF-PCL), were prepared to examine their potential as skin tissue engineering scaffolds. Raman spectra demonstrated that ACNF NPs exhibited graphitization degree with an I-D/I-G ratio of 1.05. Scanning electron microscopy (SEM) observations showed that ACNF NPs are sized 280 +/- 100 nm by diameter and 565-3322 nm by length. The NPs concentrated above 30 mu g/mL were found to exhibit toxicity with < 70% viability of NIH3T3 fibroblasts on 48 h. The ACNF-PCL nanofiber mats displayed better cell proliferation profile showing significant changes compared to PCL and ACNF@PCL mats on days 1, 3, and 5. Hence, we concluded that ACNF-PCL mats with less concentration of ACNF NPs have more potential to support cellular growth, ensuring its possible impact on skin tissue regeneration.
Files in This Item:
T202303693.pdf Download
DOI
10.1007/s42114-022-00608-x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/195561
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links