120 232

Cited 0 times in

Secreted Akkermansia muciniphila threonyl-tRNA synthetase functions to monitor and modulate immune homeostasis

Authors
 Su-Man Kim  ;  Shinhye Park  ;  Seung-Ho Hwang  ;  Eun-Young Lee  ;  Jong-Hwan Kim  ;  Ga Seul Lee  ;  Giljae Lee  ;  Dong-Ho Chang  ;  Jae-Geun Lee  ;  Jungwon Hwang  ;  Youngjin Lee  ;  Minsoo Kyung  ;  Eun-Kyoung Kim  ;  Jae-Hoon Kim  ;  Tae-Hwan Kim  ;  Jeong Hee Moon  ;  Byoung-Chan Kim  ;  GwangPyo Ko  ;  Seon-Young Kim  ;  Ji-Hwan Ryu  ;  Jeong-Soo Lee  ;  Chul-Ho Lee  ;  Jeong-Yoon Kim  ;  Sunghoon Kim  ;  Won-Jae Lee  ;  Myung Hee Kim 
Citation
 CELL HOST & MICROBE, Vol.31(6) : 1021-1037, 2023-06 
Journal Title
CELL HOST & MICROBE
ISSN
 1931-3128 
Issue Date
2023-06
MeSH
Animals ; Homeostasis ; Interleukin-10 / metabolism ; Mice ; Phosphatidylinositol 3-Kinases / metabolism ; RNA, Transfer / metabolism ; Threonine-tRNA Ligase* / metabolism ; Verrucomicrobia / metabolism
Keywords
Akkermansia muciniphila ; anti-inflammatory immune mediator ; commensal bacterium ; gut microbiota ; immune homeostasis ; inflammation ; threonyl-tRNA synthetase
Abstract
Commensal bacteria are critically involved in the establishment of tolerance against inflammatory challenges, the molecular mechanisms of which are just being uncovered. All kingdoms of life produce aminoacyl-tRNA synthetases (ARSs). Thus far, the non-translational roles of ARSs have largely been reported in eukaryotes. Here, we report that the threonyl-tRNA synthetase (AmTARS) of the gut-associated bacterium Akkermansia muciniphila is secreted and functions to monitor and modulate immune homeostasis. Secreted AmTARS triggers M2 macrophage polarization and orchestrates the production of anti-inflammatory IL-10 via its unique, evolutionary-acquired regions, which mediates specific interactions with TLR2. This interaction activates the MAPK and PI3K/AKT signaling pathways, which converge on CREB, leading to an efficient production of IL-10 and suppression of the central inflammatory mediator NF-κB. AmTARS restores IL-10-positive macrophages, increases IL-10 levels in the serum, and attenuates the pathological effects in colitis mice. Thus, commensal tRNA synthetases can act as intrinsic mediators that maintain homeostasis. © 2023 The Author(s)
Files in This Item:
T202303462.pdf Download
DOI
10.1016/j.chom.2023.05.007
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Ryu, Ji Hwan(유지환)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/195511
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links