Cited 16 times in
Secreted Akkermansia muciniphila threonyl-tRNA synthetase functions to monitor and modulate immune homeostasis
DC Field | Value | Language |
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dc.contributor.author | 유지환 | - |
dc.date.accessioned | 2023-07-12T03:07:44Z | - |
dc.date.available | 2023-07-12T03:07:44Z | - |
dc.date.issued | 2023-06 | - |
dc.identifier.issn | 1931-3128 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195511 | - |
dc.description.abstract | Commensal bacteria are critically involved in the establishment of tolerance against inflammatory challenges, the molecular mechanisms of which are just being uncovered. All kingdoms of life produce aminoacyl-tRNA synthetases (ARSs). Thus far, the non-translational roles of ARSs have largely been reported in eukaryotes. Here, we report that the threonyl-tRNA synthetase (AmTARS) of the gut-associated bacterium Akkermansia muciniphila is secreted and functions to monitor and modulate immune homeostasis. Secreted AmTARS triggers M2 macrophage polarization and orchestrates the production of anti-inflammatory IL-10 via its unique, evolutionary-acquired regions, which mediates specific interactions with TLR2. This interaction activates the MAPK and PI3K/AKT signaling pathways, which converge on CREB, leading to an efficient production of IL-10 and suppression of the central inflammatory mediator NF-κB. AmTARS restores IL-10-positive macrophages, increases IL-10 levels in the serum, and attenuates the pathological effects in colitis mice. Thus, commensal tRNA synthetases can act as intrinsic mediators that maintain homeostasis. © 2023 The Author(s) | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Cell Press | - |
dc.relation.isPartOf | CELL HOST & MICROBE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Homeostasis | - |
dc.subject.MESH | Interleukin-10 / metabolism | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Phosphatidylinositol 3-Kinases / metabolism | - |
dc.subject.MESH | RNA, Transfer / metabolism | - |
dc.subject.MESH | Threonine-tRNA Ligase* / metabolism | - |
dc.subject.MESH | Verrucomicrobia / metabolism | - |
dc.title | Secreted Akkermansia muciniphila threonyl-tRNA synthetase functions to monitor and modulate immune homeostasis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | BioMedical Science Institute (의생명과학부) | - |
dc.contributor.googleauthor | Su-Man Kim | - |
dc.contributor.googleauthor | Shinhye Park | - |
dc.contributor.googleauthor | Seung-Ho Hwang | - |
dc.contributor.googleauthor | Eun-Young Lee | - |
dc.contributor.googleauthor | Jong-Hwan Kim | - |
dc.contributor.googleauthor | Ga Seul Lee | - |
dc.contributor.googleauthor | Giljae Lee | - |
dc.contributor.googleauthor | Dong-Ho Chang | - |
dc.contributor.googleauthor | Jae-Geun Lee | - |
dc.contributor.googleauthor | Jungwon Hwang | - |
dc.contributor.googleauthor | Youngjin Lee | - |
dc.contributor.googleauthor | Minsoo Kyung | - |
dc.contributor.googleauthor | Eun-Kyoung Kim | - |
dc.contributor.googleauthor | Jae-Hoon Kim | - |
dc.contributor.googleauthor | Tae-Hwan Kim | - |
dc.contributor.googleauthor | Jeong Hee Moon | - |
dc.contributor.googleauthor | Byoung-Chan Kim | - |
dc.contributor.googleauthor | GwangPyo Ko | - |
dc.contributor.googleauthor | Seon-Young Kim | - |
dc.contributor.googleauthor | Ji-Hwan Ryu | - |
dc.contributor.googleauthor | Jeong-Soo Lee | - |
dc.contributor.googleauthor | Chul-Ho Lee | - |
dc.contributor.googleauthor | Jeong-Yoon Kim | - |
dc.contributor.googleauthor | Sunghoon Kim | - |
dc.contributor.googleauthor | Won-Jae Lee | - |
dc.contributor.googleauthor | Myung Hee Kim | - |
dc.identifier.doi | 10.1016/j.chom.2023.05.007 | - |
dc.contributor.localId | A04611 | - |
dc.relation.journalcode | J00484 | - |
dc.identifier.eissn | 1934-6069 | - |
dc.identifier.pmid | 37269833 | - |
dc.subject.keyword | Akkermansia muciniphila | - |
dc.subject.keyword | anti-inflammatory immune mediator | - |
dc.subject.keyword | commensal bacterium | - |
dc.subject.keyword | gut microbiota | - |
dc.subject.keyword | immune homeostasis | - |
dc.subject.keyword | inflammation | - |
dc.subject.keyword | threonyl-tRNA synthetase | - |
dc.contributor.alternativeName | Ryu, Ji Hwan | - |
dc.contributor.affiliatedAuthor | 유지환 | - |
dc.citation.volume | 31 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1021 | - |
dc.citation.endPage | 1037 | - |
dc.identifier.bibliographicCitation | CELL HOST & MICROBE, Vol.31(6) : 1021-1037, 2023-06 | - |
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