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Viscoelastic Property of the Brain Assessed With Magnetic Resonance Elastography and Its Association With Glymphatic System in Neurologically Normal Individuals
DC Field | Value | Language |
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dc.contributor.author | 이승구 | - |
dc.contributor.author | 주비오 | - |
dc.date.accessioned | 2023-07-12T02:39:15Z | - |
dc.date.available | 2023-07-12T02:39:15Z | - |
dc.date.issued | 2023-06 | - |
dc.identifier.issn | 1229-6929 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195359 | - |
dc.description.abstract | Objective: To investigate the feasibility of assessing the viscoelastic properties of the brain using magnetic resonance elastography (MRE) and a novel MRE transducer to determine the relationship between the viscoelastic properties and glymphatic function in neurologically normal individuals. Materials and Methods: This prospective study included 47 neurologically normal individuals aged 23–74 years (male-tofemale ratio, 21:26). The MRE was acquired using a gravitational transducer based on a rotational eccentric mass as the driving system. The magnitude of the complex shear modulus | - |
dc.description.abstract | G* | - |
dc.description.abstract | and the phase angle φ were measured in the centrum semiovale area. To evaluate glymphatic function, the Diffusion Tensor Image Analysis Along the Perivascular Space (DTI-ALPS) method was utilized and the ALPS index was calculated. Univariable and multivariable (variables with P < 0.2 from the univariable analysis) linear regression analyses were performed for | - |
dc.description.abstract | G* | - |
dc.description.abstract | and φ and included sex, age, normalized white matter hyperintensity (WMH) volume, brain parenchymal volume, and ALPS index as covariates. Results: In the univariable analysis for | - |
dc.description.abstract | G* | - |
dc.description.abstract | , age (P = 0.005), brain parenchymal volume (P = 0.152), normalized WMH volume (P = 0.011), and ALPS index (P = 0.005) were identified as candidates with P < 0.2. In the multivariable analysis, only the ALPS index was independently associated with | - |
dc.description.abstract | G* | - |
dc.description.abstract | , showing a positive relationship (β = 0.300, P = 0.029). For φ, normalized WMH volume (P = 0.128) and ALPS index (P = 0.015) were identified as candidates for multivariable analysis, and only the ALPS index was independently associated with φ (β = 0.057, P = 0.039). Conclusion: Brain MRE using a gravitational transducer is feasible in neurologically normal individuals over a wide age range. The significant correlation between the viscoelastic properties of the brain and glymphatic function suggests that a more organized or preserved microenvironment of the brain parenchyma is associated with a more unimpeded glymphatic fluid flow. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Society of Radiology | - |
dc.relation.isPartOf | KOREAN JOURNAL OF RADIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Brain / diagnostic imaging | - |
dc.subject.MESH | Elasticity Imaging Techniques* / methods | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glymphatic System* / diagnostic imaging | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Magnetic Resonance Imaging / methods | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Prospective Studies | - |
dc.title | Viscoelastic Property of the Brain Assessed With Magnetic Resonance Elastography and Its Association With Glymphatic System in Neurologically Normal Individuals | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | Bio Joo | - |
dc.contributor.googleauthor | So Yeon Won | - |
dc.contributor.googleauthor | Ralph Sinkus | - |
dc.contributor.googleauthor | Seung-Koo Lee | - |
dc.identifier.doi | 10.3348/kjr.2022.0992 | - |
dc.contributor.localId | A02912 | - |
dc.contributor.localId | A05842 | - |
dc.relation.journalcode | J02884 | - |
dc.identifier.eissn | 2005-8330 | - |
dc.identifier.pmid | 37271210 | - |
dc.subject.keyword | Brain | - |
dc.subject.keyword | Glymphatic system | - |
dc.subject.keyword | Magnetic resonance elastography | - |
dc.subject.keyword | Neurodegenerative disease | - |
dc.subject.keyword | Viscoelastic property | - |
dc.contributor.alternativeName | Lee, Seung Koo | - |
dc.contributor.affiliatedAuthor | 이승구 | - |
dc.contributor.affiliatedAuthor | 주비오 | - |
dc.citation.volume | 24 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 564 | - |
dc.citation.endPage | 573 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF RADIOLOGY, Vol.24(6) : 564-573, 2023-06 | - |
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