0 221

Cited 0 times in

Low skeletal muscle mass is associated with mortality in kidney transplant recipients

Authors
 Hyun Jeong Kim  ;  Namki Hong  ;  Hyung Woo Kim  ;  Jaeseok Yang  ;  Beom Seok Kim  ;  Kyu Ha Huh  ;  Myoung Soo Kim  ;  Juhan Lee 
Citation
 AMERICAN JOURNAL OF TRANSPLANTATION, Vol.23(2) : 239-247, 2023-02 
Journal Title
AMERICAN JOURNAL OF TRANSPLANTATION
ISSN
 1600-6135 
Issue Date
2023-02
MeSH
Cystatin C ; Female ; Follow-Up Studies ; Glomerular Filtration Rate ; Graft Survival ; Humans ; Kidney Transplantation* / methods ; Male ; Muscle, Skeletal ; Risk Factors ; Transplant Recipients
Keywords
clinical research/practice ; diagnostic techniques and imaging: computed tomography ; hospital readmission ; kidney transplantation/nephrology ; kidney transplantation: living donor ; patient survival
Abstract
Muscle wasting in chronic kidney disease is associated with increased cardiovascular events, morbidity, and mortality. However, whether pretransplantation skeletal muscle mass affects kidney transplantation (KT) outcomes has not been established. We analyzed 623 patients who underwent KT between 2004 and 2019. We measured the cross-sectional area of total skeletal muscle at the third lumbar vertebra level on pretransplantation computed tomography scan. The patients were grouped into low and normal skeletal muscle mass groups based on the sex-specific skeletal muscle mass index lowest quartile. During the entire follow-up period, 45 patients (7.2%) died and 56 patients (9.0%) experienced death-censored graft loss. Pretransplantation low skeletal muscle mass was independently associated with all-cause mortality (adjusted hazard ratio, 2.269; 95% confidence interval, 1.232-4.182). Low muscle mass was also associated with an increased risk of hospital readmission within 1 year after transplantation. Death-censored graft survival rates were comparable between the 2 groups. The low muscle group showed higher creatinine-based estimated glomerular filtration rates (eGFRs) than the normal muscle group. Although cystatin C-based eGFRs were measured in only one-third of patients, cystatin C-based eGFRs were comparable between the 2 groups. Pretransplantation low skeletal muscle mass index is associated with an increased risk of mortality and hospital readmission after KT. Copyright © 2022 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved.
Full Text
https://www.sciencedirect.com/science/article/pii/S1600613522292831
DOI
10.1016/j.ajt.2022.11.016
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myoung Soo(김명수) ORCID logo https://orcid.org/0000-0002-8975-8381
Kim, Beom Seok(김범석) ORCID logo https://orcid.org/0000-0002-5732-2583
Kim, Hyun Jeong(김현정)
Kim, Hyung Woo(김형우) ORCID logo https://orcid.org/0000-0002-6305-452X
Yang, Jaeseok(양재석)
Lee, Ju Han(이주한)
Huh, Kyu Ha(허규하) ORCID logo https://orcid.org/0000-0003-1364-6989
Hong, Nam Ki(홍남기) ORCID logo https://orcid.org/0000-0002-8246-1956
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/195308
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links