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Assessment of Meningeal Lymphatics in the Parasagittal Dural Space: A Prospective Feasibility Study Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging
DC Field | Value | Language |
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dc.contributor.author | 박미나 | - |
dc.contributor.author | 서상현 | - |
dc.contributor.author | 안성준 | - |
dc.contributor.author | 주비오 | - |
dc.date.accessioned | 2023-07-12T02:23:15Z | - |
dc.date.available | 2023-07-12T02:23:15Z | - |
dc.date.issued | 2023-05 | - |
dc.identifier.issn | 1229-6929 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195285 | - |
dc.description.abstract | Objective: Meningeal lymphatic vessels are predominantly located in the parasagittal dural space (PSD); these vessels drain interstitial fluids out of the brain and contribute to the glymphatic system. We aimed to investigate the ability of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in assessing the dynamic changes in the meningeal lymphatic vessels in PSD. Materials and Methods: Eighteen participants (26–71 years; male:female, 10:8), without neurological or psychiatric diseases, were prospectively enrolled and underwent DCE-MRI. Three regions of interests (ROIs) were placed on the PSD, superior sagittal sinus (SSS), and cortical vein. Early and delayed enhancement patterns and six kinetic curve-derived parameters were obtained and compared between the three ROIs. Moreover, the participants were grouped into the young (< 65 years; n = 9) or older (≥ 65 years; n = 9) groups. Enhancement patterns and kinetic curve-derived parameters in the PSD were compared between the two groups. Results: The PSD showed different enhancement patterns than the SSS and cortical veins (P < 0.001 and P < 0.001, respectively) in the early and delayed phases. The PSD showed slow early enhancement and a delayed wash-out pattern. The six kinetic curve-derived parameters of PSD was significantly different than that of the SSS and cortical vein. The PSD washout rate of older participants was significantly lower (median, 0.09; interquartile range [IQR], 0.01–0.15) than that of younger participants (median, 0.32; IQR, 0.07–0.45) (P = 0.040). Conclusion: This study shows that the dynamic changes of meningeal lymphatic vessels in PSD can be assessed with DCE-MRI, and the results are different from those of the venous structures. Our finding that delayed wash-out was more pronounced in the PSD of older participants suggests that aging may disturb the meningeal lymphatic drainage. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Society of Radiology | - |
dc.relation.isPartOf | KOREAN JOURNAL OF RADIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Brain | - |
dc.subject.MESH | Contrast Media* / chemistry | - |
dc.subject.MESH | Feasibility Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Magnetic Resonance Imaging* / methods | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Prospective Studies | - |
dc.title | Assessment of Meningeal Lymphatics in the Parasagittal Dural Space: A Prospective Feasibility Study Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | Bio Joo | - |
dc.contributor.googleauthor | Mina Park | - |
dc.contributor.googleauthor | Sung Jun Ahn | - |
dc.contributor.googleauthor | Sang Hyun Suh | - |
dc.identifier.doi | 10.3348/kjr.2022.0980 | - |
dc.contributor.localId | A01460 | - |
dc.contributor.localId | A01886 | - |
dc.contributor.localId | A02237 | - |
dc.contributor.localId | A05842 | - |
dc.relation.journalcode | J02884 | - |
dc.identifier.eissn | 2005-8330 | - |
dc.identifier.pmid | 37056159 | - |
dc.subject.keyword | Aging | - |
dc.subject.keyword | Central nervous system | - |
dc.subject.keyword | Glymphatic system | - |
dc.subject.keyword | Magnetic resonance imaging | - |
dc.subject.keyword | Meningeal lymphatic system | - |
dc.contributor.alternativeName | Park, Mina | - |
dc.contributor.affiliatedAuthor | 박미나 | - |
dc.contributor.affiliatedAuthor | 서상현 | - |
dc.contributor.affiliatedAuthor | 안성준 | - |
dc.contributor.affiliatedAuthor | 주비오 | - |
dc.citation.volume | 24 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 444 | - |
dc.citation.endPage | 453 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF RADIOLOGY, Vol.24(5) : 444-453, 2023-05 | - |
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