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흰쥐의 대동맥 허혈모델에서 이완정도의 변화

Other Titles
 Modulation of Severity of Relaxation in the Isolated Rat Aortic Tissue Model of Ischemia 
Authors
 김원옥  ;  길혜금  ;  김진호  ;  박영순 
Citation
 Journal of Korean Society of Anesthesiologist (대한마취과학회지), Vol.27(12) : 1727-1733, 1994-12 
Journal Title
Journal of Korean Society of Anesthesiologist(대한마취과학회지)
ISSN
 0302-5780 
Issue Date
1994-12
Keywords
Ischemia ; Relaxation ; Caleium ; Rat ; Aorta ; Hypoxia ; Acidosis
Abstract
The purpose of this study was undertaken to test if alteration of calcium flux across the sarcolemma or sarcoplasmic reticulum change subsequent relaxation of rat aorta in tissue model of ischemia. Thoracic aorta ring segments(2-3mm wide) were studied with solution that mimicked real ischemia condition(hypoxia, acidosis, elevated lactate levels and zero sub strate). During ischemic condition, the effect of treatments thought to decrease cytosolic cal cium were tested. Half time(t(1/2)) and degree of stabilized relaxation were 2.4+/-0.9 minutes and 17.6+/-12.1%(NE 10-7 M precontraction as 100%) for verapamil(10-6 M), 3.3+/-0.7 min- utes, 22.2+/-3.9% for low Ca2+(0.75mM) in ischemic solution. Interventions aimed to elevat- ing cytosolic calcium were also tested. 3.8+/-0.9 minutes and 68.6+/-8.1% for high (10.0 mM) Ca2+ in ischemic solution, 3.7+/-0.7 minutes, 72.8+/-3.9/. for ryanodine(3X10-9 M). 3.8+/-0.5 minutes, 53.4+/-2.6% for isoproterenol. Without any treatment or agents during ischemia, hlaf time and degree of relaxation were 4.0+/-1.7 minutes, 74.6+/-13.2%, enothelium and time independent. These data support that treatment or agent thought to reduce influx of cytosolic calcium levels exaggerated the severity of relaxation. The mechanism of relaxation in ischsmia is not completely clear, but it is suggested that a reduction of calcium influx may involved and directly related.
Files in This Item:
T199401449.pdf Download
DOI
10.4097/kjae.1994.27.12.1727
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kil, Hae Keum(길혜금)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/195160
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