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흰쥐의 대동맥 허혈모델에서 이완정도의 변화

DC Field Value Language
dc.contributor.author길혜금-
dc.date.accessioned2023-07-12T00:31:45Z-
dc.date.available2023-07-12T00:31:45Z-
dc.date.issued1994-12-
dc.identifier.issn0302-5780-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/195160-
dc.description.abstractThe purpose of this study was undertaken to test if alteration of calcium flux across the sarcolemma or sarcoplasmic reticulum change subsequent relaxation of rat aorta in tissue model of ischemia. Thoracic aorta ring segments(2-3mm wide) were studied with solution that mimicked real ischemia condition(hypoxia, acidosis, elevated lactate levels and zero sub strate). During ischemic condition, the effect of treatments thought to decrease cytosolic cal cium were tested. Half time(t(1/2)) and degree of stabilized relaxation were 2.4+/-0.9 minutes and 17.6+/-12.1%(NE 10-7 M precontraction as 100%) for verapamil(10-6 M), 3.3+/-0.7 min- utes, 22.2+/-3.9% for low Ca2+(0.75mM) in ischemic solution. Interventions aimed to elevat- ing cytosolic calcium were also tested. 3.8+/-0.9 minutes and 68.6+/-8.1% for high (10.0 mM) Ca2+ in ischemic solution, 3.7+/-0.7 minutes, 72.8+/-3.9/. for ryanodine(3X10-9 M). 3.8+/-0.5 minutes, 53.4+/-2.6% for isoproterenol. Without any treatment or agents during ischemia, hlaf time and degree of relaxation were 4.0+/-1.7 minutes, 74.6+/-13.2%, enothelium and time independent. These data support that treatment or agent thought to reduce influx of cytosolic calcium levels exaggerated the severity of relaxation. The mechanism of relaxation in ischsmia is not completely clear, but it is suggested that a reduction of calcium influx may involved and directly related.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisher대한마취과학회-
dc.relation.isPartOfJournal of Korean Society of Anesthesiologist(대한마취과학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.title흰쥐의 대동맥 허혈모델에서 이완정도의 변화-
dc.title.alternativeModulation of Severity of Relaxation in the Isolated Rat Aortic Tissue Model of Ischemia-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology and Pain Medicine (마취통증의학교실)-
dc.contributor.googleauthor김원옥-
dc.contributor.googleauthor길혜금-
dc.contributor.googleauthor김진호-
dc.contributor.googleauthor박영순-
dc.identifier.doi10.4097/kjae.1994.27.12.1727-
dc.contributor.localIdA00283-
dc.relation.journalcodeJ01540-
dc.subject.keywordIschemia-
dc.subject.keywordRelaxation-
dc.subject.keywordCaleium-
dc.subject.keywordRat-
dc.subject.keywordAorta-
dc.subject.keywordHypoxia-
dc.subject.keywordAcidosis-
dc.contributor.alternativeNameKil, Hae Keum-
dc.contributor.affiliatedAuthor길혜금-
dc.citation.volume27-
dc.citation.number12-
dc.citation.startPage1727-
dc.citation.endPage1733-
dc.identifier.bibliographicCitationJournal of Korean Society of Anesthesiologist (대한마취과학회지), Vol.27(12) : 1727-1733, 1994-12-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

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