Study objective : To determine the accuracy of the pulse oximetry in the emergency department. Study design:. Prospective, cross sectional, paired measurement of SpOz against SaOz. Setting: University affiliated hospital. Interventions. A pulse oximeter with digital probe was used to measure Spo2. Arterial blood gas was drawn at the same time to measure SaOz. Results. There were no significant difference between SpOz and SaOz when SpOz was above or less than 90%(mean>_90% =0.598+-2.665,mean<90% =2.926+-7.807;p>_90% =0. 0796,p<90% =0.0860), but all together there were significant difference(mean=1.22+_4.70; p = 0.017). Conclusion. The pulse oximetry is potentially useful in patient,s with clinical signs of acute hypoxemia and patients receiving interventions that may produce acute hypoxemia, and is a rnust device in emergency department.