만성 정신분열증 환자에 있어 Clozapine 투여에 의한 비정형적 Prolactin반응

Abstract

Objects :Typical antipsychotic drugs robustly increase prolactin both in rodents and in man. Unlike in rodents，Meltzer(1989) found that acutely administered clozapine did not increases serum prolactin levels in schizophrenia and his preliminary data suggested that prolactin levels might even be reduced during clozapine treatment Methods : We investigated the serum prolactin levels in chronic schizophrenics, who were assigned to clozapine ( N = 28) or haloperidol ( N =20) for eight weeks. Blood samples were obtained biweekly during the study period, and serum prolactin concentrations were measured by standard double-antibody radioimmunoassay. Results : The serum prolactin levels were not changed in the schizophrenic patients to whom clozapine had been administrated, otherwise marked increases in serum prolactin level were observed in the haloperidol treatment group. Conclusion :Our results suggest that clozapine differs from typical antipsychotics(e.g., haloperidol) in its failure to produce serum prolactin elevation in schizophrenic patients.