Cited 2 times in

Difference of Risk of Pancreatic Cancer in New-Onset Diabetes and Long-standing Diabetes: A Population-based Cohort Study

Authors
 Hee Seung Lee  ;  Wonjeong Chae  ;  Min Je Sung  ;  Jiyoung Keum  ;  Jung Hyun Jo  ;  Moon Jae Chung  ;  Jeong Youp Park  ;  Seung Woo Park  ;  Si Young Song  ;  Eun-Cheol Park  ;  Chung Mo Nam  ;  Sung-In Jang  ;  Seungmin Bang 
Citation
 JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol.108(6) : 1338-1347, 2023-05 
Journal Title
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
ISSN
 0021-972X 
Issue Date
2023-05
MeSH
Cohort Studies ; Diabetes Mellitus* / etiology ; Humans ; Incidence ; Male ; Pancreatic Neoplasms* / complications ; Pancreatic Neoplasms* / etiology ; Risk Factors
Keywords
early diagnosis ; long-standing DM ; new-onset DM ; pancreatic cancer
Abstract
Context: Considering the absence of methods to find pancreatic cancer early, surveillance of high-risk groups is needed for early diagnosis.

Objective: The study aimed to investigate the effect in the incidence of pancreatic cancer and the differences between new-onset diabetes

mellitus (NODM) and long-standing DM (LSDM) since NODM group is a representative high-risk group.

Methods: The Korean National Health Insurance Service–National Sample Cohort between 2002 and 2013 data were used. Regarding 88 396

people with DM (case group), we conducted a 1:1 propensity score matching to select a matched non-DM population (control group). To

investigate the interaction between DM and the time variable distinguishing NODM and LSDM, we performed a multivariate time-dependent

Cox regression analysis.

Results: The incidence of pancreatic cancer was higher in the DM group compared to the non-DM group (0.52% vs 0.16%; P < .001). The

DM group had shown different risk of pancreatic cancer development according to the duration since the DMdiagnosis (NODM hazard ratio

(HR): 3.81; 95% CI, 2.97-4.88; P < .001; LSDM HR: 1.53; 95% CI, 1.11-2.11; P < .001). When the NODM and the LSDM groups were

compared, the risk of pancreatic cancer was higher in the NODM group than in the LSDM group (HR: 1.55; P = .020). In subgroup

analysis, NODM group showed that men (HR = 4.42; 95% CI, 3.15-6.19; P < .001) and patients who were in their 50 seconds (HR = 7.54;

95% CI, 3.24-17.56; P < .001) were at a higher risk of developing pancreatic cancer than matched same sex or age control group (non-

DM population), respectively.

Conclusion: The risk of pancreatic cancer was greater in people with DM than in a non-DM population. Among people with DM, NODM

showed a higher risk of pancreatic cancer than LSDM.
Full Text
https://academic.oup.com/jcem/article/108/6/1338/6957364
DOI
10.1210/clinem/dgac728
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
Yonsei Authors
Keum, Jiyoung(금지영)
Nam, Chung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Park, Seung Woo(박승우) ORCID logo https://orcid.org/0000-0001-8230-964X
Park, Eun-Cheol(박은철) ORCID logo https://orcid.org/0000-0002-2306-5398
Park, Jeong Youp(박정엽) ORCID logo https://orcid.org/0000-0003-0110-8606
Bang, Seungmin(방승민) ORCID logo https://orcid.org/0000-0001-5209-8351
Sung, Min Je(성민제) ORCID logo https://orcid.org/0000-0001-5395-8851
Song, Si Young(송시영) ORCID logo https://orcid.org/0000-0002-1417-4314
Lee, Hee Seung(이희승) ORCID logo https://orcid.org/0000-0002-2825-3160
Jang, Sung In(장성인) ORCID logo https://orcid.org/0000-0002-0760-2878
Chung, Moon Jae(정문재) ORCID logo https://orcid.org/0000-0002-5920-8549
Jo, Jung Hyun(조중현) ORCID logo https://orcid.org/0000-0002-2641-8873
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/194270
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