0 253

Cited 1 times in

Statin use is associated with better post-operative prognosis among patients with hepatitis B virus-related hepatocellular carcinoma

Authors
 Byungyoon Yun  ;  Sang Hoon Ahn  ;  Juyeon Oh  ;  Jin-Ha Yoon  ;  Beom Kyung Kim 
Citation
 EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Vol.53(4) : e13936, 2023-04 
Journal Title
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
ISSN
 0014-2972 
Issue Date
2023-04
MeSH
Carcinoma, Hepatocellular* / pathology ; Hepatitis B virus ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors* ; Liver Neoplasms* / pathology ; Neoplasm Recurrence, Local / epidemiology ; Prognosis ; Retrospective Studies
Keywords
HCC ; chronic hepatitis B ; prognosis ; recurrence ; statin ; surgical resection
Abstract
Background: The high postoperative recurrence rate of hepatocellular carcinoma (HCC) is a significant challenge. Patient metabolic factors are potential disease modifiers and should be examined as risk factors for postoperative prognosis. Here, we assessed the association between long-term statin use and HCC recurrence after surgical resection of hepatitis B virus (HBV)-related HCC.Methods: Patients who initially underwent curative resection for HBV-related HCC between 2005 and 2015 were recruited and followed up until December 2019. Patients were classified into statin user and non-statin user groups based on whether or not they had been prescribed statins for >= 2 years. The primary outcome was HCC recurrence, and the secondary outcome was liver-related mortality. The cumulative incidence by statin use was estimated using the Kaplan-Meier method and compared using the log-rank test. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using multivariable Cox regression.Results: Among 5653 patients with a median 6.1 years of follow-up, HCC recurrence and liver-related mortality occurred in 1603 and 316 patients, respectively. The 5-year cumulative incidence of HCC recurrence in the statin user group (15.9%) was significantly lower than that in the non-user group (21.3%; p = .019). From multivariable Cox regression analysis, statin use was significantly associated with a reduced risk of HCC recurrence (aHR 0.77, 95% CI: 0.61-0.98; p = .035) and liver-related mortality (aHR 0.48, 95% CI: 0.25-0.90; p = .023).Conclusion: Long-term statin use was significantly associated with reduced risk of HCC recurrence and liver-related mortality after curative resection of HBV-related HCC.
Full Text
https://onlinelibrary.wiley.com/doi/10.1111/eci.13936
DOI
10.1111/eci.13936
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Beom Kyung(김범경) ORCID logo https://orcid.org/0000-0002-5363-2496
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Yoon, Jin Ha(윤진하) ORCID logo https://orcid.org/0000-0003-4198-2955
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/194231
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links