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Statin use is associated with better post-operative prognosis among patients with hepatitis B virus-related hepatocellular carcinoma
DC Field | Value | Language |
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dc.contributor.author | 김범경 | - |
dc.contributor.author | 안상훈 | - |
dc.contributor.author | 윤진하 | - |
dc.date.accessioned | 2023-05-31T05:37:36Z | - |
dc.date.available | 2023-05-31T05:37:36Z | - |
dc.date.issued | 2023-04 | - |
dc.identifier.issn | 0014-2972 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/194231 | - |
dc.description.abstract | Background: The high postoperative recurrence rate of hepatocellular carcinoma (HCC) is a significant challenge. Patient metabolic factors are potential disease modifiers and should be examined as risk factors for postoperative prognosis. Here, we assessed the association between long-term statin use and HCC recurrence after surgical resection of hepatitis B virus (HBV)-related HCC.Methods: Patients who initially underwent curative resection for HBV-related HCC between 2005 and 2015 were recruited and followed up until December 2019. Patients were classified into statin user and non-statin user groups based on whether or not they had been prescribed statins for >= 2 years. The primary outcome was HCC recurrence, and the secondary outcome was liver-related mortality. The cumulative incidence by statin use was estimated using the Kaplan-Meier method and compared using the log-rank test. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using multivariable Cox regression.Results: Among 5653 patients with a median 6.1 years of follow-up, HCC recurrence and liver-related mortality occurred in 1603 and 316 patients, respectively. The 5-year cumulative incidence of HCC recurrence in the statin user group (15.9%) was significantly lower than that in the non-user group (21.3%; p = .019). From multivariable Cox regression analysis, statin use was significantly associated with a reduced risk of HCC recurrence (aHR 0.77, 95% CI: 0.61-0.98; p = .035) and liver-related mortality (aHR 0.48, 95% CI: 0.25-0.90; p = .023).Conclusion: Long-term statin use was significantly associated with reduced risk of HCC recurrence and liver-related mortality after curative resection of HBV-related HCC. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Carcinoma, Hepatocellular* / pathology | - |
dc.subject.MESH | Hepatitis B virus | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hydroxymethylglutaryl-CoA Reductase Inhibitors* | - |
dc.subject.MESH | Liver Neoplasms* / pathology | - |
dc.subject.MESH | Neoplasm Recurrence, Local / epidemiology | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Statin use is associated with better post-operative prognosis among patients with hepatitis B virus-related hepatocellular carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Byungyoon Yun | - |
dc.contributor.googleauthor | Sang Hoon Ahn | - |
dc.contributor.googleauthor | Juyeon Oh | - |
dc.contributor.googleauthor | Jin-Ha Yoon | - |
dc.contributor.googleauthor | Beom Kyung Kim | - |
dc.identifier.doi | 10.1111/eci.13936 | - |
dc.contributor.localId | A00487 | - |
dc.contributor.localId | A02226 | - |
dc.contributor.localId | A04616 | - |
dc.relation.journalcode | J00814 | - |
dc.identifier.eissn | 1365-2362 | - |
dc.identifier.pmid | 36504405 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/eci.13936 | - |
dc.subject.keyword | HCC | - |
dc.subject.keyword | chronic hepatitis B | - |
dc.subject.keyword | prognosis | - |
dc.subject.keyword | recurrence | - |
dc.subject.keyword | statin | - |
dc.subject.keyword | surgical resection | - |
dc.contributor.alternativeName | Kim, Beom Kyung | - |
dc.contributor.affiliatedAuthor | 김범경 | - |
dc.contributor.affiliatedAuthor | 안상훈 | - |
dc.contributor.affiliatedAuthor | 윤진하 | - |
dc.citation.volume | 53 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | e13936 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Vol.53(4) : e13936, 2023-04 | - |
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