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Statin use is associated with better post-operative prognosis among patients with hepatitis B virus-related hepatocellular carcinoma

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dc.contributor.author김범경-
dc.contributor.author안상훈-
dc.contributor.author윤진하-
dc.date.accessioned2023-05-31T05:37:36Z-
dc.date.available2023-05-31T05:37:36Z-
dc.date.issued2023-04-
dc.identifier.issn0014-2972-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/194231-
dc.description.abstractBackground: The high postoperative recurrence rate of hepatocellular carcinoma (HCC) is a significant challenge. Patient metabolic factors are potential disease modifiers and should be examined as risk factors for postoperative prognosis. Here, we assessed the association between long-term statin use and HCC recurrence after surgical resection of hepatitis B virus (HBV)-related HCC.Methods: Patients who initially underwent curative resection for HBV-related HCC between 2005 and 2015 were recruited and followed up until December 2019. Patients were classified into statin user and non-statin user groups based on whether or not they had been prescribed statins for >= 2 years. The primary outcome was HCC recurrence, and the secondary outcome was liver-related mortality. The cumulative incidence by statin use was estimated using the Kaplan-Meier method and compared using the log-rank test. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using multivariable Cox regression.Results: Among 5653 patients with a median 6.1 years of follow-up, HCC recurrence and liver-related mortality occurred in 1603 and 316 patients, respectively. The 5-year cumulative incidence of HCC recurrence in the statin user group (15.9%) was significantly lower than that in the non-user group (21.3%; p = .019). From multivariable Cox regression analysis, statin use was significantly associated with a reduced risk of HCC recurrence (aHR 0.77, 95% CI: 0.61-0.98; p = .035) and liver-related mortality (aHR 0.48, 95% CI: 0.25-0.90; p = .023).Conclusion: Long-term statin use was significantly associated with reduced risk of HCC recurrence and liver-related mortality after curative resection of HBV-related HCC.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-
dc.relation.isPartOfEUROPEAN JOURNAL OF CLINICAL INVESTIGATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHCarcinoma, Hepatocellular* / pathology-
dc.subject.MESHHepatitis B virus-
dc.subject.MESHHumans-
dc.subject.MESHHydroxymethylglutaryl-CoA Reductase Inhibitors*-
dc.subject.MESHLiver Neoplasms* / pathology-
dc.subject.MESHNeoplasm Recurrence, Local / epidemiology-
dc.subject.MESHPrognosis-
dc.subject.MESHRetrospective Studies-
dc.titleStatin use is associated with better post-operative prognosis among patients with hepatitis B virus-related hepatocellular carcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorByungyoon Yun-
dc.contributor.googleauthorSang Hoon Ahn-
dc.contributor.googleauthorJuyeon Oh-
dc.contributor.googleauthorJin-Ha Yoon-
dc.contributor.googleauthorBeom Kyung Kim-
dc.identifier.doi10.1111/eci.13936-
dc.contributor.localIdA00487-
dc.contributor.localIdA02226-
dc.contributor.localIdA04616-
dc.relation.journalcodeJ00814-
dc.identifier.eissn1365-2362-
dc.identifier.pmid36504405-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/10.1111/eci.13936-
dc.subject.keywordHCC-
dc.subject.keywordchronic hepatitis B-
dc.subject.keywordprognosis-
dc.subject.keywordrecurrence-
dc.subject.keywordstatin-
dc.subject.keywordsurgical resection-
dc.contributor.alternativeNameKim, Beom Kyung-
dc.contributor.affiliatedAuthor김범경-
dc.contributor.affiliatedAuthor안상훈-
dc.contributor.affiliatedAuthor윤진하-
dc.citation.volume53-
dc.citation.number4-
dc.citation.startPagee13936-
dc.identifier.bibliographicCitationEUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Vol.53(4) : e13936, 2023-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers

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